Levels of proinflammatory cytokines in plasma after pneumoccoccal immunization in human immunodeficiency virus type 1-infected patients

Hernan Valdez, Scott Purvis, Robert Asaad, Ian Valerio, Beverly E. Sha, Alan L. Landay, Michael M. Lederman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

To ascertain if immunization with pneumococcal polysaccharide vaccine is associated with rises in the levels of proinflammatory cytokines in the plasma of human immunodeficiency virus type 1 (HIV-1)-infected patients, the levels of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) were measured serially after immunization. IL-6 levels rose an average of 2.2- and 2.1-fold 6 and 8 h after immunization, respectively, but TNF-α levels remained unchanged. The levels of these cytokines were stable in unimmunized controls. Immunization with pneumococcal polysaccharide vaccine induces increases in the levels of IL-6 in the plasma of persons with HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)427-428
Number of pages2
JournalClinical and Diagnostic Laboratory Immunology
Volume6
Issue number3
DOIs
StatePublished - May 1999
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)

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