Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19

Stacy L. Sell, Donald S. Prough, Harris A. Weisz, Steve G. Widen, Helen L. Hellmich

Research output: Contribution to journalArticlepeer-review

Abstract

Many important questions remain regarding severe acute respiratory syndrome coronavirus- 2 (SARS-CoV-2), the viral pathogen responsible for COVID-19. These questions include the mechanisms explaining the high percentage of asymptomatic but highly infectious individuals, the wide variability in disease susceptibility, and the mechanisms of longlasting debilitating effects. Bioinformatic analysis of four coronavirus datasets representing previous outbreaks (SARS-CoV-1 and MERS-CoV), as well as SARS-CoV-2, revealed evidence of diverse host factors that appear to be coopted to facilitate virus-induced suppression of interferon-induced innate immunity, promotion of viral replication and subversion and/or evasion of antiviral immune surveillance. These host factors merit further study given their postulated roles in COVID-19-induced loss of smell and brain, heart, vascular, lung, liver, and gut dysfunction.

Original languageEnglish (US)
Article numbere0257965
JournalPloS one
Volume16
Issue number9 September
DOIs
StatePublished - Sep 2021
Externally publishedYes

ASJC Scopus subject areas

  • General

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