Life shortening in RFM and BALB/c mice as a function of radiation quality, dose, and dose rate

J. B. Storer, L. J. Serrano, E. B. Darden, M. C. Jernigan, R. L. Ullrich

Research output: Contribution to journalArticle

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Abstract

A population of nearly 30,000 RFM and 11,000 BALB/c mice were exposed to graded radiation doses of γ-rays at a high (40 to 45 rad/min) or intermediate (8.3 rad/day) dose rate, or to fission neutrons at a high (5 to 25 rad/min) or low (1 rad/day) dose rate. Effects on life shortening are reported. The dose-response curve for γ rays in RFM female mice at the high rate showed multiple changes in slope. In the region of 0 to 50 rad, the relationship between life shortening and dose could be described by a dose squared or a linear-dose-squared model with the dose-squared component predominating above ~4 rad. For RFM and BALB/c female mice irradiated at the intermediate dose rate, the curve was linear over the entire range of doses tested. Linear dose-response relationships were also observed with neutrons at both dose rates over the lower end of the dose range. The relative biological effectiveness of neutrons in the 0- to 50-rad range for RFM female mice irradiated at high dose rates was proportional to the -0.5 power of neutron dose, i.e., the RBE increased with decreasing total dose. γ rays were less effective in shortening life when delivered at an intermediate dose rate than at a high dose rate at high total doses for both strains. For the RFM, the low-dose rate neutron irradiation at low total doses was less effective than the high dose rate, while no dose-rate effect was observed for BALB/c mice in the low dose range.

Original languageEnglish
Pages (from-to)122-161
Number of pages40
JournalRadiation Research
Volume78
Issue number1
DOIs
StatePublished - 1979
Externally publishedYes

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Neutrons
shortenings
mice
Radiation
dosage
radiation
Relative Biological Effectiveness
neutrons
rays
Population
dose response

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Biophysics
  • Radiation

Cite this

Storer, J. B., Serrano, L. J., Darden, E. B., Jernigan, M. C., & Ullrich, R. L. (1979). Life shortening in RFM and BALB/c mice as a function of radiation quality, dose, and dose rate. Radiation Research, 78(1), 122-161. https://doi.org/10.2307/3575012

Life shortening in RFM and BALB/c mice as a function of radiation quality, dose, and dose rate. / Storer, J. B.; Serrano, L. J.; Darden, E. B.; Jernigan, M. C.; Ullrich, R. L.

In: Radiation Research, Vol. 78, No. 1, 1979, p. 122-161.

Research output: Contribution to journalArticle

Storer, JB, Serrano, LJ, Darden, EB, Jernigan, MC & Ullrich, RL 1979, 'Life shortening in RFM and BALB/c mice as a function of radiation quality, dose, and dose rate', Radiation Research, vol. 78, no. 1, pp. 122-161. https://doi.org/10.2307/3575012
Storer, J. B. ; Serrano, L. J. ; Darden, E. B. ; Jernigan, M. C. ; Ullrich, R. L. / Life shortening in RFM and BALB/c mice as a function of radiation quality, dose, and dose rate. In: Radiation Research. 1979 ; Vol. 78, No. 1. pp. 122-161.
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