Lifestyle intervention and/or statins for the reduction of C-reactive protein in type 2 diabetes: From the look AHEAD study

L. Maria Belalcazar, Steven M. Haffner, Wei Lang, Ron C. Hoogeveen, Julia Rushing, Dawn C. Schwenke, Russell P. Tracy, F. Xavier Pi-Sunyer, Andrea M. Kriska, Christie M. Ballantyne

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Objective: Cardiovascular risk remains high despite statin use. Overweight/obese diabetic persons usually have normal/low LDL-cholesterol but high C-reactive protein (CRP) levels. We aimed to examine the effects of intensive lifestyle intervention for weight loss (ILI) on CRP levels in overweight/obese diabetic individuals by statin use. Design and Methods: Look AHEAD was a randomized trial in overweight/obese type 2 diabetic individuals testing whether ILI would reduce cardiovascular mortality, when compared to usual care. CRP changes in 1,431 participants with biomarker levels, who remained on or off statin treatment for 1 year, were evaluated. Results: The reduction in CRP levels with ILI at 1 year in men and women on statins was -44.9 and -42.3%, respectively, compared to -13.7 and -21.0% for those on statins and usual care (P < 0.0001). At 1 year, median CRP levels were: 1.8 mg L -1 in participants randomized to ILI on statin therapy; 2.6 mg L -1 for those on statins randomized to usual care and 2.9 mg L -1 for participants not on statins but randomized to ILI. Weight loss was associated with 1-year CRP reduction (P < 0.0001) in statin and nonstatin users. Conclusions: Our findings suggest that in overweight/obese diabetic persons, ILI and statin therapy may have substantial additive anti-inflammatory benefits.

Original languageEnglish (US)
Pages (from-to)944-950
Number of pages7
JournalObesity
Volume21
Issue number5
DOIs
StatePublished - May 1 2013

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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    Belalcazar, L. M., Haffner, S. M., Lang, W., Hoogeveen, R. C., Rushing, J., Schwenke, D. C., Tracy, R. P., Pi-Sunyer, F. X., Kriska, A. M., & Ballantyne, C. M. (2013). Lifestyle intervention and/or statins for the reduction of C-reactive protein in type 2 diabetes: From the look AHEAD study. Obesity, 21(5), 944-950. https://doi.org/10.1002/oby.20431