Light-induced fluorescence of the human cervix decreases after prostaglandin application for induction of labor at term

Cordula T. Fittkow, Holger Maul, Gayle Olson, Elizabeth Martin, Lynette B. MacKay, George R. Saade, Robert E. Garfield

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Objective: To define the changes in cervical light-induced fluorescence (LIF), an index of cross-linked collagen, after the use of locally applied prostaglandin preparations for labor induction at term and the correlation between LIF and Bishop-Score. Study design: The characteristic LIF of cervical collagen was measured from the surface of the cervix using a specially designed instrument (collascope) in 41 gravidas undergoing labor induction at term by prostaglandins. LIF and Bishop-Score were obtained directly before and 4 h after the administration of prostaglandin. Paired Student's t-test, Wilcoxon Signed Rank test, Linear Regression, Spearman correlation and Fisher Exact test were used as appropriate. Results: Cervical LIF decreased significantly after prostaglandin application (0.982 ± 0.04 [before] to 0.885 ± 0.037 [after], p = 0.025). The decrease in LIF correlated with the initial LIF before PG-application (r = 0.61). The Bishop-Score increased in all 41 patients. No correlation was found between LIF versus Bishop-Score. Conclusions: Cervical application of prostaglandins decreases the amount of cross-linked collagen as measured by LIF. This effect was observed only in patients with a prior high cross-linked collagen.

Original languageEnglish (US)
Pages (from-to)62-66
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number1
StatePublished - Nov 1 2005


  • Cervical ripening
  • Collascope
  • Cross-links
  • Dinoprostone
  • Labor induction
  • Light-induced fluorescence
  • Misoprostol
  • Prostaglandins

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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