Lighting the way to host-directed immunotherapeutics

Sarah van Tol; Adam Hage; Ricardo Rajsbaum

doi:10.1016/j.chembiol.2022.06.009

Lighting the way to host-directed immunotherapeutics

Sarah van Tol
, Adam Hage
, Ricardo Rajsbaum

Research output: Contribution to journal › Comment/debate › peer-review

1 Scopus citations

Abstract

Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to screen for small molecules and identify Gilteritinib, which enhances interferon induction and antagonizes virus replication.

Original language	English (US)
Pages (from-to)	1067-1070
Number of pages	4
Journal	Cell Chemical Biology
Volume	29
Issue number	7
DOIs	https://doi.org/10.1016/j.chembiol.2022.06.009
State	Published - Jul 21 2022
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2022.06.009

Cite this

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title = "Lighting the way to host-directed immunotherapeutics",

abstract = "Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to screen for small molecules and identify Gilteritinib, which enhances interferon induction and antagonizes virus replication.",

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AU - van Tol, Sarah

AU - Hage, Adam

AU - Rajsbaum, Ricardo

PY - 2022/7/21

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N2 - Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to screen for small molecules and identify Gilteritinib, which enhances interferon induction and antagonizes virus replication.

AB - Developing broad-spectrum, host-directed antiviral therapeutics can be adapted to combat emerging viruses. In this issue of Cell Chemical Biology, Maarifi and colleagues implement a Nano luciferase reporter-based protein complementation assay to screen for small molecules and identify Gilteritinib, which enhances interferon induction and antagonizes virus replication.

UR - https://www.scopus.com/pages/publications/85134771695

UR - https://www.scopus.com/pages/publications/85134771695#tab=citedBy

U2 - 10.1016/j.chembiol.2022.06.009

DO - 10.1016/j.chembiol.2022.06.009

M3 - Comment/debate

C2 - 35868235

AN - SCOPUS:85134771695

SN - 2451-9456

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SP - 1067

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JO - Cell Chemical Biology

JF - Cell Chemical Biology

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Lighting the way to host-directed immunotherapeutics

Abstract

ASJC Scopus subject areas

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