Limb salvage from a multidisciplinary treatment approach for skeletal and soft tissue sarcomas of the extremity

D. L. Morton, F. R. Eilber, Courtney Townsend, T. T. Grant, J. Mirra, T. H. Weisenburger

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Multimodality management of extremity skeletal and soft tissue sarcomas with preoperative intra arterial Adriamycin and radiation therapy, radical surgical resection and postoperative chemotherapy or chemo immunotherapy has resulted in preservation of a functional extremity in 13 of 14 patients. Seven of 8 patients with Stage IIIA and IIIB soft tissue sarcomas, managed with preoperative intra arterial Adriamycin and radiation therapy, followed by en bloc soft tissue resection, and 6 patients with bone sarcomas managed by preoperative treatment, followed by bone resection and replacement with cadaver bone allografts, remained free of disease from 4 to 34 months. The results of the combined modality approach were significantly better than the results obtained in patients managed by surgical resection alone, or by combination of operation with another single modality, both in terms of short term recurrence free survival and salvage of a functional extremity.

Original languageEnglish (US)
Pages (from-to)268-278
Number of pages11
JournalAnnals of Surgery
Volume184
Issue number3
StatePublished - 1976
Externally publishedYes

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Limb Salvage
Sarcoma
Extremities
Bone and Bones
Doxorubicin
Radiotherapy
Therapeutics
Cadaver
Immunotherapy
Allografts
Recurrence
Drug Therapy
Survival

ASJC Scopus subject areas

  • Surgery

Cite this

Morton, D. L., Eilber, F. R., Townsend, C., Grant, T. T., Mirra, J., & Weisenburger, T. H. (1976). Limb salvage from a multidisciplinary treatment approach for skeletal and soft tissue sarcomas of the extremity. Annals of Surgery, 184(3), 268-278.

Limb salvage from a multidisciplinary treatment approach for skeletal and soft tissue sarcomas of the extremity. / Morton, D. L.; Eilber, F. R.; Townsend, Courtney; Grant, T. T.; Mirra, J.; Weisenburger, T. H.

In: Annals of Surgery, Vol. 184, No. 3, 1976, p. 268-278.

Research output: Contribution to journalArticle

Morton, DL, Eilber, FR, Townsend, C, Grant, TT, Mirra, J & Weisenburger, TH 1976, 'Limb salvage from a multidisciplinary treatment approach for skeletal and soft tissue sarcomas of the extremity', Annals of Surgery, vol. 184, no. 3, pp. 268-278.
Morton, D. L. ; Eilber, F. R. ; Townsend, Courtney ; Grant, T. T. ; Mirra, J. ; Weisenburger, T. H. / Limb salvage from a multidisciplinary treatment approach for skeletal and soft tissue sarcomas of the extremity. In: Annals of Surgery. 1976 ; Vol. 184, No. 3. pp. 268-278.
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