Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight

Rebecca Blue, Jeffery C. Chancellor, Erik L. Antonsen, Tina M. Bayuse, Vernie R. Daniels, Virginia E. Wotring

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

As human spaceflight seeks to expand beyond low-Earth orbit, NASA and its international partners face numerous challenges related to ensuring the safety of their astronauts, including the need to provide a safe and effective pharmacy for long-duration spaceflight. Historical missions have relied upon frequent resupply of onboard pharmaceuticals; as a result, there has been little study into the effects of long-term exposure of pharmaceuticals to the space environment. Of particular concern are the long-term effects of space radiation on drug stability, especially as missions venture away from the protective proximity of the Earth. Here we highlight the risk of space radiation to pharmaceuticals during exploration spaceflight, identifying the limitations of current understanding. We further seek to identify ways in which these limitations could be addressed through dedicated research efforts aimed toward the rapid development of an effective pharmacy for future spaceflight endeavors.

Original languageEnglish (US)
Article number15
Journalnpj Microgravity
Volume5
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

space flight
Space Flight
extraterrestrial radiation
Drug products
drug
Radiation
long term effects
drugs
astronauts
duration
aerospace environments
low Earth orbits
radiation
Earth (planet)
Pharmaceutical Preparations
proximity
safety
United States National Aeronautics and Space Administration
Astronauts
Drug Stability

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Materials Science (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Agricultural and Biological Sciences (miscellaneous)
  • Physics and Astronomy (miscellaneous)
  • Space and Planetary Science

Cite this

Blue, R., Chancellor, J. C., Antonsen, E. L., Bayuse, T. M., Daniels, V. R., & Wotring, V. E. (2019). Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight. npj Microgravity, 5(1), [15]. https://doi.org/10.1038/s41526-019-0076-1

Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight. / Blue, Rebecca; Chancellor, Jeffery C.; Antonsen, Erik L.; Bayuse, Tina M.; Daniels, Vernie R.; Wotring, Virginia E.

In: npj Microgravity, Vol. 5, No. 1, 15, 01.12.2019.

Research output: Contribution to journalArticle

Blue, R, Chancellor, JC, Antonsen, EL, Bayuse, TM, Daniels, VR & Wotring, VE 2019, 'Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight', npj Microgravity, vol. 5, no. 1, 15. https://doi.org/10.1038/s41526-019-0076-1
Blue, Rebecca ; Chancellor, Jeffery C. ; Antonsen, Erik L. ; Bayuse, Tina M. ; Daniels, Vernie R. ; Wotring, Virginia E. / Limitations in predicting radiation-induced pharmaceutical instability during long-duration spaceflight. In: npj Microgravity. 2019 ; Vol. 5, No. 1.
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