Limited evolution of West Nile virus has occurred during its southwesterly spread in the United States

David W C Beasley, C. Todd Davis, Hilda Guzman, Dana L. Vanlandingham, Amelia P A Travassos Da Rosa, Ray E. Parsons, Stephen Higgs, Robert B. Tesh, Alan D T Barrett

Research output: Contribution to journalArticle

92 Scopus citations

Abstract

Analysis of partial nucleotide sequences of nine West Nile virus strains isolated in southeast Texas during June-August 2002 revealed a maximum of 0.35% nucleotide variation from a New York 1999 strain. Two sequence subtypes were identified that differed from each other by approximately 0.5%, suggesting multiple introductions of virus to this area. Analysis of sequences from cloned PCR products for one strain revealed up to 0.6% divergence from the consensus sequence at the subpopulation level. The presence of unique patterns of small numbers of mutations in North American West Nile strains studied to date may suggest the absence of a strong selective pressure to drive the emergence of dominant variants.

Original languageEnglish (US)
Pages (from-to)190-195
Number of pages6
JournalVirology
Volume309
Issue number2
DOIs
StatePublished - May 10 2003

ASJC Scopus subject areas

  • Virology

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    Beasley, D. W. C., Davis, C. T., Guzman, H., Vanlandingham, D. L., Travassos Da Rosa, A. P. A., Parsons, R. E., Higgs, S., Tesh, R. B., & Barrett, A. D. T. (2003). Limited evolution of West Nile virus has occurred during its southwesterly spread in the United States. Virology, 309(2), 190-195. https://doi.org/10.1016/S0042-6822(03)00150-8