Limited nonrandom chromosomal aberrations in a recurrent adenoid cystic carcinoma of the parotid gland

Adel K. El-Naggar, Mercedes Lovell, David Callender, Ann M. Killary

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We present the cytogenetic, interphase fluorescence in-situ hybridization (FISH) and DNA content findings in a clinically aggressive adenoid cystic carcinoma (ADCC) of the parotid gland. The tumor manifested diploid chromosomal and DNA content by cytogenetic, interphase FISH and flow cytometry. G-banding analysis revealed inv(5)(p15.2q33) and t(6;15)(q25;q15) as the only structural alterations in all 30 metaphases examined. The limited structural abnormalities found in this recurrent lesion suggest that they may constitute a primary or early event in the development of this tumor. The involvement of 6q region in our tumor and in some of the previously reported ADCC supports the association between this region and the evolution of at least a subset of these tumors.

Original languageEnglish (US)
Pages (from-to)66-69
Number of pages4
JournalCancer Genetics and Cytogenetics
Volume109
Issue number1
DOIs
StatePublished - Feb 1999
Externally publishedYes

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Adenoid Cystic Carcinoma
Parotid Gland
Chromosome Aberrations
Interphase
Fluorescence In Situ Hybridization
Cytogenetics
Neoplasms
DNA
Metaphase
Diploidy
Flow Cytometry

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Limited nonrandom chromosomal aberrations in a recurrent adenoid cystic carcinoma of the parotid gland. / El-Naggar, Adel K.; Lovell, Mercedes; Callender, David; Killary, Ann M.

In: Cancer Genetics and Cytogenetics, Vol. 109, No. 1, 02.1999, p. 66-69.

Research output: Contribution to journalArticle

El-Naggar, Adel K. ; Lovell, Mercedes ; Callender, David ; Killary, Ann M. / Limited nonrandom chromosomal aberrations in a recurrent adenoid cystic carcinoma of the parotid gland. In: Cancer Genetics and Cytogenetics. 1999 ; Vol. 109, No. 1. pp. 66-69.
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