Lineage and stage specificity of isotype switching in humans

G. V. Borzillo, M. D. Cooper, L. F. Bertoli, A. Landay, R. Castleberry, P. D. Burrows

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The lineage and stage specificity of human isotype switch recombination was investigated by examining the IgH gene configuration in 61 hemopoietic malignancies representing different stages of B and T cell development. An unexpectedly high frequency (20%) of IgM-producing B cell leukemias and lymphomas had undergone C(H) gene rearrangements and deletions consistent with attempted switch recombination. These C(H) gene alterations were found on productive, non-productive, and 14q+ chromosomes. These data support the concept of a non-specific (common) switch recombinase activity that is often ineffective. No evidence of such switch recombination was found in 25 μ- or μ+ pre-B cell leukemias with the single exception of a μ- pre-B leukemia in which subsets of the cells were producing γ- or α-H chains. The switch recombinase activity may be restricted to the B cell lineage, inasmuch as C(H) gene deletions were not observed in T lineage malignancies.

Original languageEnglish (US)
Pages (from-to)3625-3633
Number of pages9
JournalJournal of Immunology
Issue number10
StatePublished - 1988
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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