Linear growth response to exogenous growth hormone in Prader-Willi syndrome

Phillip Lee, D. M. Wilson, L. Rountree, R. L. Hintz, R. G. Rosenfeld

Research output: Contribution to journalArticle

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Abstract

Linear growth retardation and adult short stature are usual characteristics of Prader-Willi syndrome. Several lines of evidence suggest that a deficiency in growth hormone (GH) secretion may contribute to this abnormal growth pattern. We have recently reported observations in 4 children with Prader-Willi syndrome treated with GH. This report extends our observations in 2 of these cases. Both cases had abnormally low growth rate, normal stimulated GH levels, and low somatomedin-C levels prior to therapy. GH treatment led to significant increases in linear growth rate and somatomedin-C levels. An additive effecft of oxandrolone therapy on linear growth rate was demonstrated in one case. Our results support the possibility of a neurosecretory GH deficiency in Prader-Willi syndrome and suggest a need for further investigations.

Original languageEnglish (US)
Pages (from-to)865-871
Number of pages7
JournalAmerican Journal of Medical Genetics
Volume28
Issue number4
StatePublished - 1987
Externally publishedYes

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Prader-Willi Syndrome
Growth Hormone
Growth
Insulin-Like Growth Factor I
Oxandrolone
Therapeutics

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Lee, P., Wilson, D. M., Rountree, L., Hintz, R. L., & Rosenfeld, R. G. (1987). Linear growth response to exogenous growth hormone in Prader-Willi syndrome. American Journal of Medical Genetics, 28(4), 865-871.

Linear growth response to exogenous growth hormone in Prader-Willi syndrome. / Lee, Phillip; Wilson, D. M.; Rountree, L.; Hintz, R. L.; Rosenfeld, R. G.

In: American Journal of Medical Genetics, Vol. 28, No. 4, 1987, p. 865-871.

Research output: Contribution to journalArticle

Lee, P, Wilson, DM, Rountree, L, Hintz, RL & Rosenfeld, RG 1987, 'Linear growth response to exogenous growth hormone in Prader-Willi syndrome', American Journal of Medical Genetics, vol. 28, no. 4, pp. 865-871.
Lee, Phillip ; Wilson, D. M. ; Rountree, L. ; Hintz, R. L. ; Rosenfeld, R. G. / Linear growth response to exogenous growth hormone in Prader-Willi syndrome. In: American Journal of Medical Genetics. 1987 ; Vol. 28, No. 4. pp. 865-871.
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