Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum

Su Jin Yi, Lawrence D. Snell, Kenneth M. Johnson

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-d-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [3H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [3H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.

Original languageEnglish (US)
Pages (from-to)147-151
Number of pages5
JournalBrain Research
Volume445
Issue number1
DOIs
StatePublished - Mar 29 1988

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Keywords

  • Cerebellum
  • Cortex
  • N-Methyl-d-aspartic acid receptor
  • Norepinephrine
  • Phencyclidine receptor
  • Release assay

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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