Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum

Su Jin Yi; Lawrence D. Snell; Kenneth M. Johnson

doi:10.1016/0006-8993(88)91084-0

Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum

Su Jin Yi, Lawrence D. Snell, Kenneth M. Johnson

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-d-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [³H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [³H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [³H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.

Original language	English (US)
Pages (from-to)	147-151
Number of pages	5
Journal	Brain Research
Volume	445
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(88)91084-0
State	Published - Mar 29 1988
Externally published	Yes

Keywords

Cerebellum
Cortex
N-Methyl-d-aspartic acid receptor
Norepinephrine
Phencyclidine receptor
Release assay

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(88)91084-0

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title = "Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum",

abstract = "It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-d-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [3H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [3H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.",

keywords = "Cerebellum, Cortex, N-Methyl-d-aspartic acid receptor, Norepinephrine, Phencyclidine receptor, Release assay",

author = "Yi, {Su Jin} and Snell, {Lawrence D.} and Johnson, {Kenneth M.}",

note = "Funding Information: This work was supported by the U.S.D.H.H.S., Grant DA-02073.",

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T1 - Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum

AU - Yi, Su Jin

AU - Snell, Lawrence D.

AU - Johnson, Kenneth M.

N1 - Funding Information: This work was supported by the U.S.D.H.H.S., Grant DA-02073.

PY - 1988/3/29

Y1 - 1988/3/29

N2 - It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-d-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [3H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [3H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.

AB - It has been suggested that phencyclidine (PCP) receptors may not be linked with N-methyl-d-aspartate (NMDA) receptors in all brain areas. We found that NMDA enhanced [3H]TCP (a PCP analog) binding in extensively washed cortical, but not cerebellar membranes. However, PCP potently inhibited NMDA-induced [3H]norepinephrine release from cerebellar slices in a concentration-dependent manner, suggesting that a subtype of cerebellar PCP receptors is functionally linked with NMDA receptors. It is suggested that this subtype cannot be demonstrated by [3H]TCP binding because of the predominance of low affinity PCP receptors in the cerebellum.

KW - Cerebellum

KW - Cortex

KW - N-Methyl-d-aspartic acid receptor

KW - Norepinephrine

KW - Phencyclidine receptor

KW - Release assay

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Linkage between phencyclidine (PCP) and N-methyl-d-aspartate (NMDA) receptors in the cerebellum

Abstract

Keywords

ASJC Scopus subject areas

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