Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise

C. A. Raguso, A. R. Coggan, A. Gastaldelli, L. S. Sidossis, E. J. Bastyr, R. R. Wolfe

Research output: Contribution to journalArticle

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Abstract

Insulin-dependent diabetes mellitus (IDDM) is characterized by a metabolic and hormonal disarray that may be more evident during exercise. However, the metabolic response to exercise of different intensities has not been evaluated in IDDM. We therefore used stable isotope techniques and indirect calorimetry to quantify substrate kinetics and oxidation during 30 min of exercise at 45 and 75% of maximal oxygen uptake (V̇O(2max)) in seven men with IDDM (D group) infused with insulin at a constant basal rate. Normal control subjects (C group) matched for age, weight, and V̇O(2max) were also studied. During moderate exercise, glucose uptake (R(d)) was lower in the D than in the C group (15.3 ± 1.0 vs. 20.8 ± 1.6 μmol · min-1 · kg-1; P < 0.05). Carbohydrate oxidation also tended to be lower in the D group (71.0 ± 7.2 vs. 87.5 ± 10.6 μmol · min-1 · kg-1; P = 0.08). The D group relied on fat oxidation to a greater extent than did the C group (16.9 ± 1.1 vs. 10.4 ± 1.6 μmol · min-1 · kg-1; P < 0.05). The enhanced fat oxidation was not due to increased lipolysis because no differences occurred in glycerol release (R(a)) or in plasma free fatty acid R(a) or concentration, and the source of the extra lipid appeared to be intramuscular fat stores. These differences in substrate metabolism were not evident during exercise at 75% of V̇O(2max). The lower glucose uptake and oxidation in the diabetic subjects during moderate, but not intense, exercise suggest that glucose metabolism is regulated differently depending on exercise intensity. During moderate exercise, glucose uptake into muscle seems to be limiting, and the higher intramuscular triglyceride oxidation observed in IDDM might be a compensatory adaptation needed to maintain energy supply.

Original languageEnglish (US)
Pages (from-to)1066-1074
Number of pages9
JournalDiabetes
Volume44
Issue number9
StatePublished - 1995

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Carbohydrate Metabolism
Type 1 Diabetes Mellitus
Lipid Metabolism
Exercise
Glucose
Fats
Dilatation and Curettage
Indirect Calorimetry
Lipolysis
Nonesterified Fatty Acids
Isotopes
Glycerol
Triglycerides
Research Design
Age Groups
Carbohydrates
Insulin
Oxygen
Lipids
Weights and Measures

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Raguso, C. A., Coggan, A. R., Gastaldelli, A., Sidossis, L. S., Bastyr, E. J., & Wolfe, R. R. (1995). Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise. Diabetes, 44(9), 1066-1074.

Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise. / Raguso, C. A.; Coggan, A. R.; Gastaldelli, A.; Sidossis, L. S.; Bastyr, E. J.; Wolfe, R. R.

In: Diabetes, Vol. 44, No. 9, 1995, p. 1066-1074.

Research output: Contribution to journalArticle

Raguso, CA, Coggan, AR, Gastaldelli, A, Sidossis, LS, Bastyr, EJ & Wolfe, RR 1995, 'Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise', Diabetes, vol. 44, no. 9, pp. 1066-1074.
Raguso CA, Coggan AR, Gastaldelli A, Sidossis LS, Bastyr EJ, Wolfe RR. Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise. Diabetes. 1995;44(9):1066-1074.
Raguso, C. A. ; Coggan, A. R. ; Gastaldelli, A. ; Sidossis, L. S. ; Bastyr, E. J. ; Wolfe, R. R. / Lipid and carbohydrate metabolism in IDDM during moderate and intense exercise. In: Diabetes. 1995 ; Vol. 44, No. 9. pp. 1066-1074.
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