Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans

Xiao Jun Zhang, David L. Chinkes, Asle Aarsland, David Herndon, Robert R. Wolfe

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Whereas diet-induced obese rabbits have been used to study various aspects of obesity, alterations of lipid metabolism in this model have not been clarified. This study aimed to compare plasma nonesterified fatty acid (NEFA) and triglyceride (TG) kinetics in obese and lean rabbits by means of U- 13C16-palmitate infusion. Young female rabbits consumed either a high-fat diet (49% energy from fat) ad libitum to develop obesity (n = 6) or a normal diet (7.9% energy from fat) as lean control (n = 5). After 10 wk of feeding, the body weight of obese rabbits (5.33 ± 0.05 kg) was greater (P < 0.001) than that of lean rabbits (3.89 ± 0.07 kg). The obese rabbits had higher concentrations of plasma NEFA and TG and a greater rate of fatty acid (FA) turnover. Whereas the fractional secretion rates of hepatic TG did not differ, 100% of hepatic secretory TG was synthesized from plasma NEFA in the lean rabbits compared to 59% in the obese rabbits (P < 0.001). In the lean rabbits, hepatic lipase-mediated hydrolysis of lipoprotein TG did not contribute to the FA pool for synthesis of secretory TG, consistent with the naturally occurring deficit in hepatic lipase in this species. We conclude that lipid metabolism in diet-induced obese rabbits is similar to that in obese humans. The deficiency in hepatic lipase in rabbits simplifies the quantitation of hepatic lipid kinetics.

Original languageEnglish (US)
Pages (from-to)515-518
Number of pages4
JournalJournal of Nutrition
Volume138
Issue number3
StatePublished - Mar 2008

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Lipid Metabolism
lipid metabolism
rabbits
Diet
Rabbits
diet
triacylglycerols
Triglycerides
liver
Liver
Lipase
Nonesterified Fatty Acids
free fatty acids
obesity
Fatty Acids
lipids
Obesity
Fats
fatty acids
kinetics

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Zhang, X. J., Chinkes, D. L., Aarsland, A., Herndon, D., & Wolfe, R. R. (2008). Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans. Journal of Nutrition, 138(3), 515-518.

Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans. / Zhang, Xiao Jun; Chinkes, David L.; Aarsland, Asle; Herndon, David; Wolfe, Robert R.

In: Journal of Nutrition, Vol. 138, No. 3, 03.2008, p. 515-518.

Research output: Contribution to journalArticle

Zhang, XJ, Chinkes, DL, Aarsland, A, Herndon, D & Wolfe, RR 2008, 'Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans', Journal of Nutrition, vol. 138, no. 3, pp. 515-518.
Zhang XJ, Chinkes DL, Aarsland A, Herndon D, Wolfe RR. Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans. Journal of Nutrition. 2008 Mar;138(3):515-518.
Zhang, Xiao Jun ; Chinkes, David L. ; Aarsland, Asle ; Herndon, David ; Wolfe, Robert R. / Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans. In: Journal of Nutrition. 2008 ; Vol. 138, No. 3. pp. 515-518.
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