Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: Effect of drugs with different molecular mechanisms

V. Sorrenti, C. Di Giacomo, M. Renis, A. Russo, C. La Delfa, J. R. Perez-Polo, A. Vanella

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.

Original languageEnglish (US)
Pages (from-to)185-189
Number of pages5
JournalDrugs under Experimental and Clinical Research
Volume20
Issue number5
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology (medical)

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