Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion

Effect of drugs with different molecular mechanisms

V. Sorrenti, C. Di Giacomo, M. Renis, A. Russo, C. La Delfa, J. R. Perez-Polo, A. Vanella

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Abstract

    In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.

    Original languageEnglish (US)
    Pages (from-to)185-189
    Number of pages5
    JournalDrugs under Experimental and Clinical Research
    Volume20
    Issue number5
    StatePublished - 1994

    Fingerprint

    Lipid Peroxidation
    Reperfusion
    Antioxidants
    Pharmaceutical Preparations
    Calcium
    Allopurinol
    Deferoxamine
    Diltiazem
    Xanthine Oxidase
    Verapamil
    Vitamin E
    Cerebral Cortex
    Reactive Oxygen Species
    Iron

    ASJC Scopus subject areas

    • Molecular Medicine
    • Pharmacology (medical)
    • Drug Discovery
    • Pharmacology

    Cite this

    Sorrenti, V., Di Giacomo, C., Renis, M., Russo, A., La Delfa, C., Perez-Polo, J. R., & Vanella, A. (1994). Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: Effect of drugs with different molecular mechanisms. Drugs under Experimental and Clinical Research, 20(5), 185-189.

    Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion : Effect of drugs with different molecular mechanisms. / Sorrenti, V.; Di Giacomo, C.; Renis, M.; Russo, A.; La Delfa, C.; Perez-Polo, J. R.; Vanella, A.

    In: Drugs under Experimental and Clinical Research, Vol. 20, No. 5, 1994, p. 185-189.

    Research output: Contribution to journalArticle

    Sorrenti, V, Di Giacomo, C, Renis, M, Russo, A, La Delfa, C, Perez-Polo, JR & Vanella, A 1994, 'Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: Effect of drugs with different molecular mechanisms', Drugs under Experimental and Clinical Research, vol. 20, no. 5, pp. 185-189.
    Sorrenti, V. ; Di Giacomo, C. ; Renis, M. ; Russo, A. ; La Delfa, C. ; Perez-Polo, J. R. ; Vanella, A. / Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion : Effect of drugs with different molecular mechanisms. In: Drugs under Experimental and Clinical Research. 1994 ; Vol. 20, No. 5. pp. 185-189.
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