Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: Effect of drugs with different molecular mechanisms

V. Sorrenti; C. Di Giacomo; M. Renis; A. Russo; C. La Delfa; J. R. Perez-Polo; A. Vanella

Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: Effect of drugs with different molecular mechanisms

V. Sorrenti, C. Di Giacomo, M. Renis, A. Russo, C. La Delfa, J. R. Perez-Polo, A. Vanella

Research output: Contribution to journal › Article › peer-review

Abstract

In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.

Original language	English (US)
Pages (from-to)	185-189
Number of pages	5
Journal	Drugs under Experimental and Clinical Research
Volume	20
Issue number	5
State	Published - 1994

ASJC Scopus subject areas

Molecular Medicine
Pharmacology
Drug Discovery
Pharmacology (medical)

Cite this

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title = "Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: Effect of drugs with different molecular mechanisms",

abstract = "In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.",

author = "V. Sorrenti and {Di Giacomo}, C. and M. Renis and A. Russo and {La Delfa}, C. and Perez-Polo, {J. R.} and A. Vanella",

note = "Funding Information: 1 This investigation was supported by FAPESP, S{\~a}o Paulo, Brazil (Project Nos. 97/07400-0 and 99/01628-4), the Brazilian Research Council (CNPq) (Brasilia, Brazil), and the International Atomic Energy Agency (IAEA), Vienna, Austria (Technical Cooperation Project BRA 2/012).",

year = "1994",

language = "English (US)",

volume = "20",

pages = "185--189",

journal = "Drugs under Experimental and Clinical Research",

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TY - JOUR

T1 - Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion

T2 - Effect of drugs with different molecular mechanisms

AU - Sorrenti, V.

AU - Di Giacomo, C.

AU - Renis, M.

AU - Russo, A.

AU - La Delfa, C.

AU - Perez-Polo, J. R.

AU - Vanella, A.

N1 - Funding Information: 1 This investigation was supported by FAPESP, São Paulo, Brazil (Project Nos. 97/07400-0 and 99/01628-4), the Brazilian Research Council (CNPq) (Brasilia, Brazil), and the International Atomic Energy Agency (IAEA), Vienna, Austria (Technical Cooperation Project BRA 2/012).

PY - 1994

Y1 - 1994

N2 - In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.

AB - In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.

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SN - 0378-6501

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JO - Drugs under Experimental and Clinical Research

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IS - 5

ER -

Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: Effect of drugs with different molecular mechanisms

Abstract

ASJC Scopus subject areas

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