Abstract
In the present study the authors investigated the effect of pretreatment with exogenous antioxidants such as deferoxamine (iron chelating drug), allopurinol (competitive inhibitor of xanthine oxidase) and vitamin E (scavenger of oxygen free radicals) on lipid peroxidation in rat cerebral cortex after post-ischaemic reperfusion, and on the survival rate. The effect of pretreatment with two calcium-antagonist drugs (diltiazem and verapamil) was also evaluated under the same experimental conditions. Pretreatment with exogenous antioxidants and with calcium-antagonist drugs significantly decreased cerebral conjugated diene levels (index of lipoperoxidation) with a concomitant increase in survival with respect to untreated ischaemic rats.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 185-189 |
| Number of pages | 5 |
| Journal | Drugs under Experimental and Clinical Research |
| Volume | 20 |
| Issue number | 5 |
| State | Published - 1994 |
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
- Drug Discovery
- Pharmacology (medical)