Although the role of oxidant-antioxidant metabolism in total ischemia and reperfusion in the central nervous system and cardiac myocardium have been well studied, less is known about the consequences of partial ischemic episodes. Here we show that reperfusion contributes to free radical formation as judged by conjugated diene formation. Also, antioxidants and Ca++ antagonists were able to reduce free radical formation. These results would suggest that free radical generation following ischemia and reperfusion may result from more than one injury process in cerebral cortex.
|Original language||English (US)|
|Number of pages||6|
|Journal||International Journal of Developmental Neuroscience|
|State||Published - Feb 1992|
ASJC Scopus subject areas
- Developmental Neuroscience
- Developmental Biology