Lipid peroxidation in rat cerebral cortex during post-ischemic reperfusion: Effect of exogenous antioxidants and Ca++-antagonist drugs

A. Vanella, V. Sorrenti, C. Castorina, A. Campisi, C. Di Giacomo, A. Russo, J. R. Perez-Polo

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Although the role of oxidant-antioxidant metabolism in total ischemia and reperfusion in the central nervous system and cardiac myocardium have been well studied, less is known about the consequences of partial ischemic episodes. Here we show that reperfusion contributes to free radical formation as judged by conjugated diene formation. Also, antioxidants and Ca++ antagonists were able to reduce free radical formation. These results would suggest that free radical generation following ischemia and reperfusion may result from more than one injury process in cerebral cortex.

Original languageEnglish (US)
Pages (from-to)75-80
Number of pages6
JournalInternational Journal of Developmental Neuroscience
Volume10
Issue number1
DOIs
StatePublished - Feb 1992
Externally publishedYes

Keywords

  • CNS
  • antioxidant
  • calcium
  • ischemia
  • peroxidation

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Developmental Biology

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