Lipid raft microdomains and neurotransmitter signalling

John A. Allen, Robyn A. Halverson-Tamboli, Mark M. Rasenick

Research output: Contribution to journalReview article

592 Scopus citations

Abstract

Lipid rafts are specialized structures on the plasma membrane that have an altered lipid composition as well as links to the cytoskeleton. It has been proposed that these structures are membrane domains in which neurotransmitter signalling might occur through a clustering of receptors and components of receptor-activated signalling cascades. The localization of these proteins in lipid rafts, which is affected by the cytoskeleton, also influences the potency and efficacy of neurotransmitter receptors and transporters. The effect of lipid rafts on neurotransmitter signalling has also been implicated in neurological and psychiatric diseases.

Original languageEnglish (US)
Pages (from-to)128-140
Number of pages13
JournalNature Reviews Neuroscience
Volume8
Issue number2
DOIs
StatePublished - Feb 1 2007
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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