Lithium in vitro enhances interleukin-2 production by t cells from patients with systemic lupus erythematosus

Eugene J. Kucharz, Stanistaw J. Sierakowski, James Goodwin

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. the decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. the increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is belived that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired itra-cellular signal transduction in the T cells from patients with SLE.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalImmunopharmacology and Immunotoxicology
Volume15
Issue number5
DOIs
StatePublished - 1993
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

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