Lithium in vitro enhances interleukin-2 production by t cells from patients with systemic lupus erythematosus

Eugene J. Kucharz, Stanistaw J. Sierakowski, James Goodwin

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. the decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. the increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is belived that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired itra-cellular signal transduction in the T cells from patients with SLE.

Original languageEnglish (US)
Pages (from-to)515-523
Number of pages9
JournalImmunopharmacology and Immunotoxicology
Volume15
Issue number5
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

T-cells
Lithium
Systemic Lupus Erythematosus
Interleukin-2
T-Lymphocytes
Lithium Chloride
Signal transduction
Inositol
Cell culture
Cellular Immunity
Cytosol
Signal Transduction
Blood
In Vitro Techniques

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Pharmacology
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Lithium in vitro enhances interleukin-2 production by t cells from patients with systemic lupus erythematosus. / Kucharz, Eugene J.; Sierakowski, Stanistaw J.; Goodwin, James.

In: Immunopharmacology and Immunotoxicology, Vol. 15, No. 5, 1993, p. 515-523.

Research output: Contribution to journalArticle

@article{877d3a52b3ec4cd49c5555511238daf9,
title = "Lithium in vitro enhances interleukin-2 production by t cells from patients with systemic lupus erythematosus",
abstract = "Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. the decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. the increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is belived that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired itra-cellular signal transduction in the T cells from patients with SLE.",
author = "Kucharz, {Eugene J.} and Sierakowski, {Stanistaw J.} and James Goodwin",
year = "1993",
doi = "10.3109/08923979309019728",
language = "English (US)",
volume = "15",
pages = "515--523",
journal = "Immunopharmacology and Immunotoxicology",
issn = "0892-3973",
publisher = "Informa Healthcare",
number = "5",

}

TY - JOUR

T1 - Lithium in vitro enhances interleukin-2 production by t cells from patients with systemic lupus erythematosus

AU - Kucharz, Eugene J.

AU - Sierakowski, Stanistaw J.

AU - Goodwin, James

PY - 1993

Y1 - 1993

N2 - Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. the decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. the increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is belived that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired itra-cellular signal transduction in the T cells from patients with SLE.

AB - Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. the decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. the increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is belived that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired itra-cellular signal transduction in the T cells from patients with SLE.

UR - http://www.scopus.com/inward/record.url?scp=0027365316&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027365316&partnerID=8YFLogxK

U2 - 10.3109/08923979309019728

DO - 10.3109/08923979309019728

M3 - Article

C2 - 8301016

AN - SCOPUS:0027365316

VL - 15

SP - 515

EP - 523

JO - Immunopharmacology and Immunotoxicology

JF - Immunopharmacology and Immunotoxicology

SN - 0892-3973

IS - 5

ER -