Abstract
Cellular immunity is impaired in patients with systemic lupus erythematosus (SLE). A decreased production of interleukin-2 by T cells isolated from blood of patients with SLE was found. the decrease correlated with severity of the disease. It was shown that incubation in vitro of T cells with 5 mM of lithium chloride augmented interleukin-2 production. the increase in cultures of T cells from patients with SLE was higher that than in healthy individuals. It is belived that lithium increases the cytosol inositol triphosphate level and subsequently augmented impaired itra-cellular signal transduction in the T cells from patients with SLE.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 515-523 |
| Number of pages | 9 |
| Journal | Immunopharmacology and Immunotoxicology |
| Volume | 15 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1993 |
| Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Toxicology
- Pharmacology