Liver hemodynamics during portal venous endotoxemia in swine

L. Halvorsen, R. Roth, R. A. Gunther, E. Firoozmand, A. M. Buoncristiani, George Kramer

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The acute hemodynamic response of the liver to portal endotoxemia was measured in six isoflurane anesthetized pigs in which volume support was used to maintain normal cardiac output. After baseline monitoring, bacterial endotoxin (LPS) was infused over 1 hr into a mesenteric vein at a rate of 1 μg · kg-1 · hr-1, and monitoring was continued for 1 hr postinfusion. Peak vasoconstriction occurred during LPS infusion in both the hepatic artery (resistance ↑ 349% of baseline, P < 0.05) and the liver's portal circulation (resistance ↑ 159% of baseline, P < 0.05). Increased vascular resistance was also detected in lung (↑ 433% of baseline) and intestine (↑ 130% of baseline) at the midpoint of the LPS infusion. The non-splanchnic circulation, defined for our analysis as all of the peripheral circulation except the portal and hepatic arterial circulation, generally exhibited little change in vascular resistance during LPS infusion. LPS was incompletely cleared by the liver, but secondary clearance by the lung prevented large increases in the LPS concentration of arterial blood. During the first hour postinfusion, the systemic vascular resistances subsequently decreased to near normal in all vascular beds, with the exception of the liver's portal circulation. A sustained and secondary increase in vascular resistance of the liver's portal circulation and portal vein pressure occurred during the first hour after LPS infusion. We conclude that most of the vasoconstriction in the acute response to portal endotoxemia occurs in the liver and lung, organs directly exposed to elevated levels of endotoxins.

Original languageEnglish (US)
Pages (from-to)166-175
Number of pages10
JournalCirculatory Shock
Volume41
Issue number3
StatePublished - 1993

Fingerprint

Liver Circulation
Endotoxemia
Vascular Resistance
Swine
Hemodynamics
Liver
Vasoconstriction
Endotoxins
Lung
Portal Pressure
Mesenteric Veins
Hepatic Artery
Isoflurane
Portal Vein
Cardiac Output
Intestines
Blood Vessels

Keywords

  • endotoxin
  • hepatic blood flow
  • pig
  • portal vein
  • sepsis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Halvorsen, L., Roth, R., Gunther, R. A., Firoozmand, E., Buoncristiani, A. M., & Kramer, G. (1993). Liver hemodynamics during portal venous endotoxemia in swine. Circulatory Shock, 41(3), 166-175.

Liver hemodynamics during portal venous endotoxemia in swine. / Halvorsen, L.; Roth, R.; Gunther, R. A.; Firoozmand, E.; Buoncristiani, A. M.; Kramer, George.

In: Circulatory Shock, Vol. 41, No. 3, 1993, p. 166-175.

Research output: Contribution to journalArticle

Halvorsen, L, Roth, R, Gunther, RA, Firoozmand, E, Buoncristiani, AM & Kramer, G 1993, 'Liver hemodynamics during portal venous endotoxemia in swine', Circulatory Shock, vol. 41, no. 3, pp. 166-175.
Halvorsen L, Roth R, Gunther RA, Firoozmand E, Buoncristiani AM, Kramer G. Liver hemodynamics during portal venous endotoxemia in swine. Circulatory Shock. 1993;41(3):166-175.
Halvorsen, L. ; Roth, R. ; Gunther, R. A. ; Firoozmand, E. ; Buoncristiani, A. M. ; Kramer, George. / Liver hemodynamics during portal venous endotoxemia in swine. In: Circulatory Shock. 1993 ; Vol. 41, No. 3. pp. 166-175.
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