Loa loa infection as a cause of migratory angioedema: Report of three cases from the texas medical center

Robert M. Rakita, A. Clinton White, Marcia A. Kielhofner

Research output: Contribution to journalArticle

30 Scopus citations


Loa loa is a filarial parasite that is endemic in West and Central Africa. Expatriates infected with L. loa commonly develop characteristic migratory angioedema called Calabar swellings. We describe three patients who presented with classical Calabar swellings for whom the diagnosis of loiasis was delayed. Unusual features that were present included a leukocytoclastic vasculitis seen on skin biopsy (case 1), a relatively short exposure to an area of endemicity (cases 1 and 3), and a normal eosinophil count on initial evaluation (cases 2 and 3). We discuss the characteristic clinical manifestations of, pathological findings of, and therapy for loiasis. With the increased frequency of international travel, L. loa infection must be considered in the differential diagnosis for patients with migratory angioedema, urticarial vasculitis, or eosinophilia.

Original languageEnglish (US)
Pages (from-to)691-694
Number of pages4
JournalClinical Infectious Diseases
Issue number4
StatePublished - Oct 1 1993
Externally publishedYes


ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this