Lobeline does not serve as a reinforcer in rats

Steven B. Harrod, Linda P. Dwoskin, Thomas A. Green, Brenda J. Gehrke, Michael T. Bardo

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Rationale: Previous results demonstrated that pretreatment with lobeline attenuates d-methamphetamine self-administration in rats. Objective: The present experiments determined if lobeline serves as a reinforcer, if it decreases d-methamphetamine-induced reinstatement of d-methamphetamine self-administration, and if it activates the mesolimbic and nigrostriatal dopamine (DA) pathways in Sprague-Dawley male rats. Methods: The ability of intravenous (IV) lobeline (0.015-0.15 mg/kg per infusion) to engender responding and the ability of lobeline (0.015 and 0.05 mg/kg per infusion) to substitute for d-methamphetamine was determined using the self-administration paradigm. Experiments were also performed to determine if lobeline (1.0 and 3.0 mg/kg) reinstates responding for d-methamphetamine or alters the ability of d-methamphetamine (1.0 mg/kg per infusion) to reinstate responding following extinction. The effect of lobeline (3.0 mg/kg) or d-methamphetamine (1.0 and 3.0 mg/kg) on DA and dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens and striatum were also determined. Results: Lobeline was not self-administered and did not substitute for d-methamphetamine. Also, lobeline did not reinstate responding for d-methamphetamine following extinction nor did it alter d-methamphetamine-induced reinstatement. Furthermore, lobeline did not alter DA or DOPAC levels in the either the nucleus accumbens or striatum. Conclusions: Taken together, the present results indicate that lobeline decreases d-methamphetamine self-administration by decreasing reward, not by acting as a substitute reinforcer.

Original languageEnglish (US)
Pages (from-to)397-404
Number of pages8
Issue number4
StatePublished - Feb 2003
Externally publishedYes


  • Drug abuse
  • Extinction
  • Lobeline
  • Reinstatement
  • Self-administration
  • d-Methamphetamine

ASJC Scopus subject areas

  • Pharmacology


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