Local and systemic antibody class responses to an infectious laryngotracheitis virus vaccine strain

N. R. Da Silva Martins, A. P A Mockett, Alan Barrett, Jane K A Cook

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Chickens infected with infectious laryngotracheitis virus (ILTV) responded by producing virus-specific IgG in their sera, which increased steadily in concentration, but with slight fluctuations, until peak titres were reached 40 days post-inoculation (pi), immediately prior to the second challenge. Thereafter, following an initial lag, concentrations continued to increase for 21 days before falling slightly at the end of the experiment. In contrast, peak concentrations of ILTV-specific IgM were reached 6 days pi falling to their lowest levels by day 16, before increasing to a second peak and trough on days 26 and 32, respectively. This cyclical production of ILTV-specific IgM was confirmed in a second experiment. The pattern of production of ILTV-specific IgG, IgM and IgA, detected in tracheal washings, occurred in the same cyclical manner. IgM was produced first, peak concentrations being detected 5 days pi, whereas IgG and IgA did not peak until 10 days pi, with second peaks of each class being detected 25–30 days pi. The possibility that the cyclical antibody class response to ILTV infection is related to the previously reported intermittent pattern of re-excretion of the virus is discussed.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalAvian Pathology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Fingerprint

Gallid herpesvirus 1
Immunoglobulin Isotypes
Antibody Formation
Vaccines
vaccination
vaccines
Viruses
antibodies
Immunoglobulin M
Immunoglobulin G
Immunoglobulin A
viruses
washing
Virus Diseases
excretion
Chickens
chickens
infection
Serum

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Immunology and Microbiology(all)
  • Food Animals

Cite this

Local and systemic antibody class responses to an infectious laryngotracheitis virus vaccine strain. / Da Silva Martins, N. R.; Mockett, A. P A; Barrett, Alan; Cook, Jane K A.

In: Avian Pathology, Vol. 21, No. 1, 01.01.1992, p. 97-106.

Research output: Contribution to journalArticle

Da Silva Martins, N. R. ; Mockett, A. P A ; Barrett, Alan ; Cook, Jane K A. / Local and systemic antibody class responses to an infectious laryngotracheitis virus vaccine strain. In: Avian Pathology. 1992 ; Vol. 21, No. 1. pp. 97-106.
@article{7fd80e28c5c743b8a9f0f1211c015eaf,
title = "Local and systemic antibody class responses to an infectious laryngotracheitis virus vaccine strain",
abstract = "Chickens infected with infectious laryngotracheitis virus (ILTV) responded by producing virus-specific IgG in their sera, which increased steadily in concentration, but with slight fluctuations, until peak titres were reached 40 days post-inoculation (pi), immediately prior to the second challenge. Thereafter, following an initial lag, concentrations continued to increase for 21 days before falling slightly at the end of the experiment. In contrast, peak concentrations of ILTV-specific IgM were reached 6 days pi falling to their lowest levels by day 16, before increasing to a second peak and trough on days 26 and 32, respectively. This cyclical production of ILTV-specific IgM was confirmed in a second experiment. The pattern of production of ILTV-specific IgG, IgM and IgA, detected in tracheal washings, occurred in the same cyclical manner. IgM was produced first, peak concentrations being detected 5 days pi, whereas IgG and IgA did not peak until 10 days pi, with second peaks of each class being detected 25–30 days pi. The possibility that the cyclical antibody class response to ILTV infection is related to the previously reported intermittent pattern of re-excretion of the virus is discussed.",
author = "{Da Silva Martins}, {N. R.} and Mockett, {A. P A} and Alan Barrett and Cook, {Jane K A}",
year = "1992",
month = "1",
day = "1",
doi = "10.1080/03079459208418822",
language = "English (US)",
volume = "21",
pages = "97--106",
journal = "Avian Pathology",
issn = "0307-9457",
publisher = "Taylor and Francis Ltd.",
number = "1",

}

TY - JOUR

T1 - Local and systemic antibody class responses to an infectious laryngotracheitis virus vaccine strain

AU - Da Silva Martins, N. R.

AU - Mockett, A. P A

AU - Barrett, Alan

AU - Cook, Jane K A

PY - 1992/1/1

Y1 - 1992/1/1

N2 - Chickens infected with infectious laryngotracheitis virus (ILTV) responded by producing virus-specific IgG in their sera, which increased steadily in concentration, but with slight fluctuations, until peak titres were reached 40 days post-inoculation (pi), immediately prior to the second challenge. Thereafter, following an initial lag, concentrations continued to increase for 21 days before falling slightly at the end of the experiment. In contrast, peak concentrations of ILTV-specific IgM were reached 6 days pi falling to their lowest levels by day 16, before increasing to a second peak and trough on days 26 and 32, respectively. This cyclical production of ILTV-specific IgM was confirmed in a second experiment. The pattern of production of ILTV-specific IgG, IgM and IgA, detected in tracheal washings, occurred in the same cyclical manner. IgM was produced first, peak concentrations being detected 5 days pi, whereas IgG and IgA did not peak until 10 days pi, with second peaks of each class being detected 25–30 days pi. The possibility that the cyclical antibody class response to ILTV infection is related to the previously reported intermittent pattern of re-excretion of the virus is discussed.

AB - Chickens infected with infectious laryngotracheitis virus (ILTV) responded by producing virus-specific IgG in their sera, which increased steadily in concentration, but with slight fluctuations, until peak titres were reached 40 days post-inoculation (pi), immediately prior to the second challenge. Thereafter, following an initial lag, concentrations continued to increase for 21 days before falling slightly at the end of the experiment. In contrast, peak concentrations of ILTV-specific IgM were reached 6 days pi falling to their lowest levels by day 16, before increasing to a second peak and trough on days 26 and 32, respectively. This cyclical production of ILTV-specific IgM was confirmed in a second experiment. The pattern of production of ILTV-specific IgG, IgM and IgA, detected in tracheal washings, occurred in the same cyclical manner. IgM was produced first, peak concentrations being detected 5 days pi, whereas IgG and IgA did not peak until 10 days pi, with second peaks of each class being detected 25–30 days pi. The possibility that the cyclical antibody class response to ILTV infection is related to the previously reported intermittent pattern of re-excretion of the virus is discussed.

UR - http://www.scopus.com/inward/record.url?scp=2542606914&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2542606914&partnerID=8YFLogxK

U2 - 10.1080/03079459208418822

DO - 10.1080/03079459208418822

M3 - Article

VL - 21

SP - 97

EP - 106

JO - Avian Pathology

JF - Avian Pathology

SN - 0307-9457

IS - 1

ER -