Local recurrence of breast cancer in the stereotactic core needle biopsy site

Case reports and review of the literature

Celia Chao, Michael H. Torosian, Marcia C. Boraas, Elin R. Sigurdson, John P. Hoffman, Burton L. Eisenberg, Barbara Fowble

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Early mammographic detection of nonpalpable breast lesions has led to the increasing use of stereotactic core biopsies for tissue diagnosis. Tumor seeding the needle tract is a theorectical concern; the incidence and clinical significance of this potential complication are unknown. We report three cases of subcutaneous breast cancer recurrence at the stereotactic biopsy site after definitive treatment of the primary breast tumor. Two cases were clinically evident and relevant; the third was detected in the preclinical, microscopic state. All three patients underwent multiple passes during stereotactic large-core biopsies (14 gauge needle) followed by modified radical mastectomy. Two patients developed a subcutaneous recurrence at the site of the previous biopsy 12 and 17 months later; one had excision of the skin and dermis at the time of mastectomy revealing tumor cells locally. In summary, clinically relevant recurrence from tumor cells seeding the needle tract is reported in two patients after definitive surgical therapy (without adjuvant radiation therapy). Often, the biopsy site is outside the boundaries of surgical resection. Since the core needle biopsy exit site represents a potential area of malignant seeding and subsequent tumor recurrence, we recommend excising the stereotactic core biopsy tract at the time of definitive surgical resection of the primary tumor.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalBreast Journal
Volume7
Issue number2
DOIs
StatePublished - 2001
Externally publishedYes

Fingerprint

Large-Core Needle Biopsy
Breast Neoplasms
Biopsy
Recurrence
Needles
Neoplasms
Modified Radical Mastectomy
Mastectomy
Dermis
Breast
Radiotherapy
Skin
Incidence
Therapeutics

Keywords

  • Breast cancer recurrence
  • Needle tract seeding
  • Stereotactic biopsy

ASJC Scopus subject areas

  • Internal Medicine
  • Oncology

Cite this

Local recurrence of breast cancer in the stereotactic core needle biopsy site : Case reports and review of the literature. / Chao, Celia; Torosian, Michael H.; Boraas, Marcia C.; Sigurdson, Elin R.; Hoffman, John P.; Eisenberg, Burton L.; Fowble, Barbara.

In: Breast Journal, Vol. 7, No. 2, 2001, p. 124-127.

Research output: Contribution to journalArticle

Chao, Celia ; Torosian, Michael H. ; Boraas, Marcia C. ; Sigurdson, Elin R. ; Hoffman, John P. ; Eisenberg, Burton L. ; Fowble, Barbara. / Local recurrence of breast cancer in the stereotactic core needle biopsy site : Case reports and review of the literature. In: Breast Journal. 2001 ; Vol. 7, No. 2. pp. 124-127.
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