Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin

Susan M. Carlton, Gregory L. Hargett, Richard E. Coggeshall

    Research output: Contribution to journalArticle

    308 Citations (Scopus)

    Abstract

    Immunohistochemical staining for the glutamate receptor subtypes N-methyl-d-aspartate (NMDA), kainate, and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) results in a significant number of labeled unmyelinated axons in the glabrous skin of the rat hindpaw. Injection of glutamate into the rat hindpaw results in behavioral changes interpreted as mechanical allodynia and mechanical hyperalgesia. The anatomical findings provide a reasonable explanation for the action of the exogenous peripheral glutamate, namely that activation of these receptors leads to increased primary afferent activity in unmyelinated axons and thus to pain behaviors. AMPA receptors are frequently associated with small clear vesicles in the axoplasm of the unmyelinated axons, many of which have been previously shown to contain high concentrations of glutamate. This finding indicates that these might be autoreceptors and so glutamate itself might regulate certain types of peripheral impulse traffic. The presence of peripheral glutamate receptors associated with unmyelinated axons suggests the possibility that glutamate antagonists applied peripherally might prevent or attenuate some pain-related behaviors.

    Original languageEnglish
    Pages (from-to)25-28
    Number of pages4
    JournalNeuroscience Letters
    Volume197
    Issue number1
    DOIs
    StatePublished - Sep 1 1995

    Fingerprint

    Glutamate Receptors
    Axons
    Glutamic Acid
    Skin
    Hyperalgesia
    Pain
    Autoreceptors
    Excitatory Amino Acid Antagonists
    Kainic Acid
    Aspartic Acid
    Staining and Labeling
    Injections
    bucide
    propionic acid

    Keywords

    • Kainate
    • Mechanical allodynia
    • Mechanical hyperalgesia
    • N-Methyl-d-aspartate
    • Non-N-methyl-d-aspartate
    • α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. / Carlton, Susan M.; Hargett, Gregory L.; Coggeshall, Richard E.

    In: Neuroscience Letters, Vol. 197, No. 1, 01.09.1995, p. 25-28.

    Research output: Contribution to journalArticle

    Carlton, Susan M. ; Hargett, Gregory L. ; Coggeshall, Richard E. / Localization and activation of glutamate receptors in unmyelinated axons of rat glabrous skin. In: Neuroscience Letters. 1995 ; Vol. 197, No. 1. pp. 25-28.
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