Localization of ionotropic glutamate receptors in peripheral axons of human skin

Ilka Kinkelin, Eva Bettina Bröcker, Martin Koltzenburg, Susan M. Carlton

    Research output: Contribution to journalArticle

    79 Citations (Scopus)

    Abstract

    Recent observations suggest that glutamate is important in sensory transduction in the periphery, contributing to peripheral sensitization of nociceptors and the hyperalgesia that accompanies inflammation. This study examined the presence of ionotropic glutamate receptors N-methyl-D-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazolone-4-propionic acid (AMPA) and kainate (KA) in normal human hairy skin (n=6) using immunohistochemistry at the electron microscopic level. Analysis of labeled axons at the dermal-epidermal junction demonstrated that 26.9±2, 19.5±3 and 18.5±1% of the axons analyzed were labeled for subunits of the NMDA, AMPA or KA receptors, respectively. An occasional Schwann cell process was labeled for either NMDA or KA receptors. The findings support the hypothesis that glutamate and its ionotropic receptors may play a role in the periphery in sensory processing in humans. Copyright (C) 2000 Elsevier Science Ireland Ltd.

    Original languageEnglish (US)
    Pages (from-to)149-152
    Number of pages4
    JournalNeuroscience Letters
    Volume283
    Issue number2
    DOIs
    StatePublished - Apr 7 2000

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    Ionotropic Glutamate Receptors
    Kainic Acid Receptors
    N-Methylaspartate
    Axons
    Skin
    Nociceptors
    Kainic Acid
    Schwann Cells
    Hyperalgesia
    N-Methyl-D-Aspartate Receptors
    Glutamic Acid
    Immunohistochemistry
    Electrons
    Inflammation
    propionic acid

    Keywords

    • α-Amino-3-hydroxy-5-methylisoxazolone-4-propionic acid
    • Electron microscopy
    • Hyperalgesia
    • Immunohistochemistry
    • Kainate
    • N-methyl-D-aspartate
    • Pain
    • Primary afferent

    ASJC Scopus subject areas

    • Neuroscience(all)

    Cite this

    Localization of ionotropic glutamate receptors in peripheral axons of human skin. / Kinkelin, Ilka; Bröcker, Eva Bettina; Koltzenburg, Martin; Carlton, Susan M.

    In: Neuroscience Letters, Vol. 283, No. 2, 07.04.2000, p. 149-152.

    Research output: Contribution to journalArticle

    Kinkelin, I, Bröcker, EB, Koltzenburg, M & Carlton, SM 2000, 'Localization of ionotropic glutamate receptors in peripheral axons of human skin', Neuroscience Letters, vol. 283, no. 2, pp. 149-152. https://doi.org/10.1016/S0304-3940(00)00944-7
    Kinkelin, Ilka ; Bröcker, Eva Bettina ; Koltzenburg, Martin ; Carlton, Susan M. / Localization of ionotropic glutamate receptors in peripheral axons of human skin. In: Neuroscience Letters. 2000 ; Vol. 283, No. 2. pp. 149-152.
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