Localized malignant mesothelioma

Timothy Craig Allen, Philip T. Cagle, Andrew M. Churg, Thomas V. Colby, Allen R. Gibbs, Samuel P. Hammar, Joseph M. Corson, Margaret M. Grimes, Nelson G. Ordonez, Victor Roggli, William D. Travis, Mark R. Wick

Research output: Contribution to journalArticle

113 Citations (Scopus)

Abstract

Localized malignant mesotheliomas are uncommon sharply circumscribed tumors of the serosal membranes with the microscopic appearance of diffuse malignant mesothelioma but without any evidence of diffuse spread. Little is known about their behavior. We report 23 new cases. The mean age at presentation was 63 years, and the sex ratio was approximately 2:1 (male/female). Twenty-one tumors were pleural and 2 were peritoneal. Sixteen tumors reproduced microscopic patterns of diffuse epithelial mesotheliomas, 6 had mixed epithelial and sarcomatous patterns, and 1 was purely sarcomatous. After surgical excision of the tumor, 10 of 21 patients with follow-up data were alive without evidence of disease from 18 months to 11 years after diagnosis. Patients who died had developed local recurrences and metastases, but none had diffuse pleural spread. Localized malignant mesotheliomas should be separated from diffuse malignant mesotheliomas because of their localized presentation, quite different biologic behavior, and far better prognosis.

Original languageEnglish (US)
Pages (from-to)866-873
Number of pages8
JournalAmerican Journal of Surgical Pathology
Volume29
Issue number7
DOIs
StatePublished - Jul 2005
Externally publishedYes

Fingerprint

Pleural Solitary Fibrous Tumor
Neoplasms
Mesothelioma
Sex Ratio
Neoplasm Metastasis
Recurrence
Membranes
Malignant Mesothelioma

Keywords

  • Diffuse malignant mesothelioma
  • Localized malignant mesothelioma
  • Pericarditis
  • Peritoneum
  • Pleura

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Allen, T. C., Cagle, P. T., Churg, A. M., Colby, T. V., Gibbs, A. R., Hammar, S. P., ... Wick, M. R. (2005). Localized malignant mesothelioma. American Journal of Surgical Pathology, 29(7), 866-873. https://doi.org/10.1097/01.pas.0000165529.78945.dc

Localized malignant mesothelioma. / Allen, Timothy Craig; Cagle, Philip T.; Churg, Andrew M.; Colby, Thomas V.; Gibbs, Allen R.; Hammar, Samuel P.; Corson, Joseph M.; Grimes, Margaret M.; Ordonez, Nelson G.; Roggli, Victor; Travis, William D.; Wick, Mark R.

In: American Journal of Surgical Pathology, Vol. 29, No. 7, 07.2005, p. 866-873.

Research output: Contribution to journalArticle

Allen, TC, Cagle, PT, Churg, AM, Colby, TV, Gibbs, AR, Hammar, SP, Corson, JM, Grimes, MM, Ordonez, NG, Roggli, V, Travis, WD & Wick, MR 2005, 'Localized malignant mesothelioma', American Journal of Surgical Pathology, vol. 29, no. 7, pp. 866-873. https://doi.org/10.1097/01.pas.0000165529.78945.dc
Allen TC, Cagle PT, Churg AM, Colby TV, Gibbs AR, Hammar SP et al. Localized malignant mesothelioma. American Journal of Surgical Pathology. 2005 Jul;29(7):866-873. https://doi.org/10.1097/01.pas.0000165529.78945.dc
Allen, Timothy Craig ; Cagle, Philip T. ; Churg, Andrew M. ; Colby, Thomas V. ; Gibbs, Allen R. ; Hammar, Samuel P. ; Corson, Joseph M. ; Grimes, Margaret M. ; Ordonez, Nelson G. ; Roggli, Victor ; Travis, William D. ; Wick, Mark R. / Localized malignant mesothelioma. In: American Journal of Surgical Pathology. 2005 ; Vol. 29, No. 7. pp. 866-873.
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