Locomotor stimulant effects of nornicotine: Role of dopamine

T. A. Green, R. W. Brown, S. B. Phillips, L. P. Dwoskin, M. T. Bardo

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Nornicotine (NORNIC) is a tobacco alkaloid and behaviorally active nicotine metabolite in vivo. Previous behavioral research has shown that NORNIC has locomotor stimulant and reinforcing effects in rats similar to that of nicotine. Results from the current study showed that a bilateral lesion of the nucleus accumbens decreased the locomotor stimulant effect of NORNIC across repeated injections. Pretreatment with the dopamine (DA) D1 receptor antagonist SCH23390 did not block the locomotor stimulant effect of NORNIC or the initiation of sensitization following repeated NORNIC administration. The D2 receptor antagonist eticlopride, however, blocked both the stimulant effect and the initiation of sensitization following repeated NORNIC. Additionally, NORNIC was found to increase synthesis and metabolism of DA, with a greater effect in the mesolimbic pathway compared to the nigrostriatal pathway. Taken together, these results suggest that expression of NORNIC-induced locomotor activity is dependent upon ascending dopaminergic mesolimbic projections, providing additional evidence that NORNIC plays a contributory role in tobacco dependence.

Original languageEnglish (US)
Pages (from-to)87-94
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume74
Issue number1
DOIs
StatePublished - Dec 1 2002

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Keywords

  • Activity
  • Behavior
  • DOPAC
  • Locomotion
  • Metabolism
  • Nicotine metabolite
  • Sensitization
  • Synthesis
  • Tobacco alkaloid
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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