Long ascending unmyelinated primary afferent axons in the rat dorsal column: Immunohistochemical localizations

J. T. Patterson; R. E. Coggeshall; W. T. Lee; K. Chung

doi:10.1016/0304-3940(90)90697-8

Long ascending unmyelinated primary afferent axons in the rat dorsal column: Immunohistochemical localizations

J. T. Patterson, R. E. Coggeshall, W. T. Lee, K. Chung

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The present study demonstrates a significant number of calcitonin gene-related peptide (CGRP) immunolabeled unmyelinated axons in the C₃ fasciculus gracilis of the rat. Approximately 88% of these axons are lost following dorsal rhizotomies from midthoracic levels caudally. Assuming that CGRP labels primary afferent axons, these findings support the hypothesis that there are significant numbers of long ascending unmyelinated primary afferent axons in the dorsal columns of the rat. If these findings can be generalized, they may have clinical import.

Original language	English (US)
Pages (from-to)	6-10
Number of pages	5
Journal	Neuroscience Letters
Volume	108
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(90)90697-8
State	Published - Jan 1 1990

Keywords

Calcitonin gene-related peptide
Dorsal column
Primary afferent
Unmyelinated axon

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(90)90697-8

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title = "Long ascending unmyelinated primary afferent axons in the rat dorsal column: Immunohistochemical localizations",

abstract = "The present study demonstrates a significant number of calcitonin gene-related peptide (CGRP) immunolabeled unmyelinated axons in the C3 fasciculus gracilis of the rat. Approximately 88% of these axons are lost following dorsal rhizotomies from midthoracic levels caudally. Assuming that CGRP labels primary afferent axons, these findings support the hypothesis that there are significant numbers of long ascending unmyelinated primary afferent axons in the dorsal columns of the rat. If these findings can be generalized, they may have clinical import.",

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T2 - Immunohistochemical localizations

AU - Patterson, J. T.

AU - Coggeshall, R. E.

AU - Lee, W. T.

AU - Chung, K.

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N2 - The present study demonstrates a significant number of calcitonin gene-related peptide (CGRP) immunolabeled unmyelinated axons in the C3 fasciculus gracilis of the rat. Approximately 88% of these axons are lost following dorsal rhizotomies from midthoracic levels caudally. Assuming that CGRP labels primary afferent axons, these findings support the hypothesis that there are significant numbers of long ascending unmyelinated primary afferent axons in the dorsal columns of the rat. If these findings can be generalized, they may have clinical import.

AB - The present study demonstrates a significant number of calcitonin gene-related peptide (CGRP) immunolabeled unmyelinated axons in the C3 fasciculus gracilis of the rat. Approximately 88% of these axons are lost following dorsal rhizotomies from midthoracic levels caudally. Assuming that CGRP labels primary afferent axons, these findings support the hypothesis that there are significant numbers of long ascending unmyelinated primary afferent axons in the dorsal columns of the rat. If these findings can be generalized, they may have clinical import.

KW - Calcitonin gene-related peptide

KW - Dorsal column

KW - Primary afferent

KW - Unmyelinated axon

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