Long-Term Administration of Oxandrolone Improves Lung Function in Pediatric Burned Patients

Linda Sousse, David Herndon, Ronald P. Mlcak, Jong Lee, Clark R. Andersen, Andrew Zovath, Celeste Finnerty, Oscar Suman

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Abstract

    Pulmonary dysfunction is a significant contributor to morbidity and mortality in the pediatric burned population. We have previously reported that the administration of a synthetic testosterone derivative, oxandrolone, significantly reduced hypermetabolism, and significantly increased height percentile, bone mineral content, lean body mass, and strength in pediatric burned patients. We hypothesize that the administration of oxandrolone will improve pulmonary function in burned pediatric subjects. A subset of severely burned pediatric subjects from a prospective clinical trial (n = 222) were included in our study (n = 54, 7–18 years, ≥30% TBSA burn). The subjects were previously randomized to either the control arm (n = 35) or the oxandrolone arm (0.1 mg/kg twice/day for 12 months, n = 19). Maximum voluntary ventilation, the ratio between forced expiratory volume and forced vital capacity, and diffusion capacity were measured 6 months following burn injury, and results were compared between burned subjects with and without oxandrolone administration. Maximum expired ventilation (VEmax) was also measured in a subset of burned subjects. Subjects treated with oxandrolone had a significantly higher maximum voluntary ventilation (98 ± 53 L/min vs 115 ± 56 with treatment, P = .03). During maximal exercise, subjects treated with oxandrolone had a significantly higher VEmax compared with untreated subjects (32.0 ± 8.7 L/min vs 43.7 ± 13.6 with treatment, P = .02). The administration of oxandrolone was associated with improved lung function in pediatric burned patients.

    Original languageEnglish (US)
    JournalJournal of Burn Care and Research
    DOIs
    StateAccepted/In press - May 11 2016

    Fingerprint

    Oxandrolone
    Pediatrics
    Lung
    Ventilation
    Vital Capacity
    Forced Expiratory Volume
    Bone Density
    Testosterone
    Clinical Trials
    Exercise
    Morbidity
    Mortality

    ASJC Scopus subject areas

    • Emergency Medicine
    • Rehabilitation
    • Surgery

    Cite this

    Long-Term Administration of Oxandrolone Improves Lung Function in Pediatric Burned Patients. / Sousse, Linda; Herndon, David; Mlcak, Ronald P.; Lee, Jong; Andersen, Clark R.; Zovath, Andrew; Finnerty, Celeste; Suman, Oscar.

    In: Journal of Burn Care and Research, 11.05.2016.

    Research output: Contribution to journalArticle

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    AU - Zovath, Andrew

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