TY - JOUR
T1 - Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response
AU - Santiago, Felix W.
AU - Halsey, Eric S.
AU - Siles, Crystyan
AU - Vilcarromero, Stalin
AU - Guevara, Carolina
AU - Silvas, Jesus A.
AU - Ramal, Cesar
AU - Ampuero, Julia S.
AU - Aguilar, Patricia V.
N1 - Funding Information:
HHSN27200004/D04. FWS was supported by the T32 Training grant (AI007536) in Emerging and Reemerging Infectious Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funding Information:
Funding: This research was supported by the United States Department of Defense Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center Work Unit Number: 847705.82000.25GB. B0016, the NIH 5R21AI101794-02 (PVA), Institute for Human Infection and Immunity at the University of Texas Medical Branch, and start-up funds from the Department of Pathology. PVA was also partially supported by the NIH contract HHSN272201000040I/
Funding Information:
This research was supported by the United States Department of Defense Global Emerging Infections Surveillance and Response System, a Division of the Armed Forces Health Surveillance Center Work Unit Number: 847705.82000.25GB. B0016, the NIH 5R21AI101794-02 (PVA), Institute for Human Infection and Immunity at the University of Texas Medical Branch, and start-up funds from the Department of Pathology. PVA was also partially supported by the NIH contract HHSN272201000040I/ HHSN27200004/D04. FWS was supported by the T32 Training grant (AI007536) in Emerging and Reemerging Infectious Diseases. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PY - 2015/10/23
Y1 - 2015/10/23
N2 - Mayaro virus (MAYV), an alphavirus similar to chikungunya virus (CHIKV), causes an acute debilitating disease which results in the development of long-term arthralgia in more than 50% of infected individuals. Currently, the immune response and its role in the development of MAYV-induced persistent arthralgia remain unknown. In this study, we evaluated the immune response of individuals with confirmed MAYV infection in a one-year longitudinal study carried out in Loreto, Peru. We report that MAYV infection elicits robust immune responses that result in the development of a strong neutralizing antibody response and the secretion of pro-inflammatory immune mediators. The composition of these inflammatory mediators, in some cases, differed to those previously observed for CHIKV. Key mediators such as IL-13, IL-7 and VEGF were strongly induced following MAYV infection and were significantly increased in subjects that eventually developed persistent arthralgia. Although a strong neutralizing antibody response was observed in all subjects, it was not sufficient to prevent the long-term outcomes of MAYV infection. This study provides initial immunologic insight that may eventually contribute to prognostic tools and therapeutic treatments against this emerging pathogen.
AB - Mayaro virus (MAYV), an alphavirus similar to chikungunya virus (CHIKV), causes an acute debilitating disease which results in the development of long-term arthralgia in more than 50% of infected individuals. Currently, the immune response and its role in the development of MAYV-induced persistent arthralgia remain unknown. In this study, we evaluated the immune response of individuals with confirmed MAYV infection in a one-year longitudinal study carried out in Loreto, Peru. We report that MAYV infection elicits robust immune responses that result in the development of a strong neutralizing antibody response and the secretion of pro-inflammatory immune mediators. The composition of these inflammatory mediators, in some cases, differed to those previously observed for CHIKV. Key mediators such as IL-13, IL-7 and VEGF were strongly induced following MAYV infection and were significantly increased in subjects that eventually developed persistent arthralgia. Although a strong neutralizing antibody response was observed in all subjects, it was not sufficient to prevent the long-term outcomes of MAYV infection. This study provides initial immunologic insight that may eventually contribute to prognostic tools and therapeutic treatments against this emerging pathogen.
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U2 - 10.1371/journal.pntd.0004104
DO - 10.1371/journal.pntd.0004104
M3 - Article
C2 - 26506128
AN - SCOPUS:84959148543
VL - 9
JO - PLoS Neglected Tropical Diseases
JF - PLoS Neglected Tropical Diseases
SN - 1935-2727
IS - 10
M1 - e0004104
ER -