Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

Kimberly Smith; Evgenia Aga; Ronald J. Bosch; Hernan Valdez; Elizabeth Connick; Alan Landay; Daniel Kuritzkes; Barry H. Gross; Isaac R. Francis; Joseph M. McCune; Harold Kessler; Michael Lederman

doi:10.1097/00002030-200409240-00012

Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

Kimberly Smith, Evgenia Aga, Ronald J. Bosch, Hernan Valdez, Elizabeth Connick, Alan Landay, Daniel Kuritzkes, Barry H. Gross, Isaac R. Francis, Joseph M. McCune, Harold Kessler, Michael Lederman

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm ³ after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm³ and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm ³. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.

Original language	English (US)
Pages (from-to)	1953-1956
Number of pages	4
Journal	AIDS
Volume	18
Issue number	14
DOIs	https://doi.org/10.1097/00002030-200409240-00012
State	Published - Sep 24 2004
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/00002030-200409240-00012

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Smith, K., Aga, E., Bosch, R. J., Valdez, H., Connick, E., Landay, A., Kuritzkes, D., Gross, B. H., Francis, I. R., McCune, J. M., Kessler, H., & Lederman, M. (2004). Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy. AIDS, 18(14), 1953-1956. https://doi.org/10.1097/00002030-200409240-00012

Smith, K, Aga, E, Bosch, RJ, Valdez, H, Connick, E, Landay, A, Kuritzkes, D, Gross, BH, Francis, IR, McCune, JM, Kessler, H & Lederman, M 2004, 'Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy', AIDS, vol. 18, no. 14, pp. 1953-1956. https://doi.org/10.1097/00002030-200409240-00012

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AU - Smith, Kimberly

AU - Aga, Evgenia

AU - Bosch, Ronald J.

AU - Valdez, Hernan

AU - Connick, Elizabeth

AU - Landay, Alan

AU - Kuritzkes, Daniel

AU - Gross, Barry H.

AU - Francis, Isaac R.

AU - McCune, Joseph M.

AU - Kessler, Harold

AU - Lederman, Michael

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AB - Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm 3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm 3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.

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Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

Abstract

ASJC Scopus subject areas

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