Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

Kimberly Smith; Evgenia Aga; Ronald J. Bosch; Hernan Valdez; Elizabeth Connick; Alan Landay; Daniel Kuritzkes; Barry H. Gross; Isaac R. Francis; Joseph M. McCune; Harold Kessler; Michael Lederman

doi:10.1097/00002030-200409240-00012

Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

Kimberly Smith
, Evgenia Aga
, Ronald J. Bosch
, Hernan Valdez
, Elizabeth Connick
, Alan Landay
, Daniel Kuritzkes
, Barry H. Gross
, Isaac R. Francis
, Joseph M. McCune
, Harold Kessler
, Michael Lederman

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm ³ after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm³ and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm ³. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.

Original language	English (US)
Pages (from-to)	1953-1956
Number of pages	4
Journal	AIDS
Volume	18
Issue number	14
DOIs	https://doi.org/10.1097/00002030-200409240-00012
State	Published - Sep 24 2004
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1097/00002030-200409240-00012

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Smith, K., Aga, E., Bosch, R. J., Valdez, H., Connick, E., Landay, A., Kuritzkes, D., Gross, B. H., Francis, I. R., McCune, J. M., Kessler, H., & Lederman, M. (2004). Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy. AIDS, 18(14), 1953-1956. https://doi.org/10.1097/00002030-200409240-00012

Smith, K, Aga, E, Bosch, RJ, Valdez, H, Connick, E, Landay, A, Kuritzkes, D, Gross, BH, Francis, IR, McCune, JM, Kessler, H & Lederman, M 2004, 'Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy', AIDS, vol. 18, no. 14, pp. 1953-1956. https://doi.org/10.1097/00002030-200409240-00012

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abstract = "Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm 3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm 3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.",

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T1 - Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

AU - Smith, Kimberly

AU - Aga, Evgenia

AU - Bosch, Ronald J.

AU - Valdez, Hernan

AU - Connick, Elizabeth

AU - Landay, Alan

AU - Kuritzkes, Daniel

AU - Gross, Barry H.

AU - Francis, Isaac R.

AU - McCune, Joseph M.

AU - Kessler, Harold

AU - Lederman, Michael

PY - 2004/9/24

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N2 - Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm 3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm 3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.

AB - Highly active antiretroviral therapy (HAART) initiated in advanced HIV disease is associated with CD4 lymphocyte increases (200-300 cells/mm 3 after 2-4 years), although longer-term cellular dynamics have not been studied. We observed a significant median CD4 lymphocyte increase of 126 cells/mm3 and 54 naive CD4 lymphocytes from year 3 to 6 of HAART among 20 individuals with pre-HAART CD4 cell counts of 100-300 cells/mm 3. This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART.

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AN - SCOPUS:4744352698

SN - 0269-9370

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JO - AIDS

JF - AIDS

IS - 14

ER -

Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy

Abstract

ASJC Scopus subject areas

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