Long-term depression in hippocampal interneurons: Joint requirement for pre- and postsynaptic events

Fernanda Laezza, James J. Doherty, Raymond Dingledine

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+ influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.

Original languageEnglish (US)
Pages (from-to)1411-1414
Number of pages4
JournalScience
Volume285
Issue number5432
DOIs
StatePublished - Aug 27 1999
Externally publishedYes

ASJC Scopus subject areas

  • General

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