Long-term depression in hippocampal interneurons

Joint requirement for pre- and postsynaptic events

Fernanda Laezza, James J. Doherty, Raymond Dingledine

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Long-term depression (LTD) is a well-known form of synaptic plasticity of principal neurons in the mammalian brain. Whether such changes occur in interneurons is still controversial CA3 hippocampal interneurons expressing Ca2+-permeable AMPA receptors exhibited LTD after tetanic stimulation of CA3 excitatory inputs. LTD was independent of NMDA receptors and required both Ca2+ influx through postsynaptic AMPA receptors and activation of presynaptic mGluR7-like receptors. These results point to the capability of interneurons to undergo plastic changes of synaptic strength through joint activation of pre- and postsynaptic glutamate receptors.

Original languageEnglish (US)
Pages (from-to)1411-1414
Number of pages4
JournalScience
Volume285
Issue number5432
DOIs
StatePublished - Aug 27 1999
Externally publishedYes

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Interneurons
AMPA Receptors
Joints
Neuronal Plasticity
Glutamate Receptors
N-Methyl-D-Aspartate Receptors
Neurons
Brain

ASJC Scopus subject areas

  • General

Cite this

Long-term depression in hippocampal interneurons : Joint requirement for pre- and postsynaptic events. / Laezza, Fernanda; Doherty, James J.; Dingledine, Raymond.

In: Science, Vol. 285, No. 5432, 27.08.1999, p. 1411-1414.

Research output: Contribution to journalArticle

Laezza, Fernanda ; Doherty, James J. ; Dingledine, Raymond. / Long-term depression in hippocampal interneurons : Joint requirement for pre- and postsynaptic events. In: Science. 1999 ; Vol. 285, No. 5432. pp. 1411-1414.
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