Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits

J. A. Joseph, B. Shukitt-Hale, N. A. Denisova, R. L. Prior, G. Cao, A. Martin, Giulio Taglialatela, P. C. Bickford

Research output: Contribution to journalArticle

362 Citations (Scopus)

Abstract

Recent research has indicated that increased vulnerability to oxidative stress may be the major factor involved in CNS functional declines in aging and age-related neurodegenerative diseases, and that antioxidants, e.g., vitamin E, may ameliorate or prevent these declines. Present studies examined whether long-term feeding of Fischer 344 rats, beginning when the rats were 6 months of age and continuing for 8 months, with diets supplemented with a fruit or vegetable extract identified as being high in antioxidant activity, could prevent the age-related induction of receptor-mediated signal transduction deficits that might have a behavioral component. Thus, the following parameters were examined: (1) oxotremorine-enhanced striatal dopamine release (OX-K+-ERDA), (2) cerebellar β receptor augmentation of GABA responding, (3) striatal synaptosomal 45Ca2+ clearance, (4) carbachol-stimulated GTPase activity, and (5) Morris water maze performance. The rats were given control diets or those supplemented with strawberry extracts (SE), 9.5 gm/kg dried aqueous extract (DAE), spinach (SPN 6.4 gm/kg DAE), or vitamin E (500 IU/kg). Results indicated that SPN-fed rats demonstrated the greatest retardation of age-effects on all parameters except GTPase activity, on which SE had the greatest effect whereas SE and vitamin E showed significant but equal protection against these age-induced deficits on the other parameters. For example, OX-K+-ERDA enhancement was four times greater in the SPN group than n controls. Thus, phytochemicals present in antioxidant-rich foods such as spinach may be beneficial in retarding functional age-related CNS and cognitive behavioral deficits and, perhaps, may have some benefit in neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)8047-8055
Number of pages9
JournalJournal of Neuroscience
Volume18
Issue number19
StatePublished - Oct 1 1998

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Fragaria
Spinacia oleracea
Vitamin E
Age of Onset
Corpus Striatum
Signal Transduction
Antioxidants
GTP Phosphohydrolases
Neurodegenerative Diseases
Diet
Oxotremorine
Civil Rights
GABA Receptors
Inbred F344 Rats
Phytochemicals
Carbachol
Vegetables
Fruit
Dopamine
Oxidative Stress

Keywords

  • Aging
  • Antioxidants
  • Cerebellum
  • Cogn itive behavior
  • Diet
  • Dopamine
  • GABA
  • Norepinephrine
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Joseph, J. A., Shukitt-Hale, B., Denisova, N. A., Prior, R. L., Cao, G., Martin, A., ... Bickford, P. C. (1998). Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. Journal of Neuroscience, 18(19), 8047-8055.

Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. / Joseph, J. A.; Shukitt-Hale, B.; Denisova, N. A.; Prior, R. L.; Cao, G.; Martin, A.; Taglialatela, Giulio; Bickford, P. C.

In: Journal of Neuroscience, Vol. 18, No. 19, 01.10.1998, p. 8047-8055.

Research output: Contribution to journalArticle

Joseph, J. A. ; Shukitt-Hale, B. ; Denisova, N. A. ; Prior, R. L. ; Cao, G. ; Martin, A. ; Taglialatela, Giulio ; Bickford, P. C. / Long-term dietary strawberry, spinach, or vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. In: Journal of Neuroscience. 1998 ; Vol. 18, No. 19. pp. 8047-8055.
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AU - Taglialatela, Giulio

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