Long-term histologic response to synthetic and biologic graft materials implanted in the vagina and abdomen of a rabbit model

Lisa M. Pierce, Arundhati Rao, Shannon S. Baumann, Jocylen E. Glassberg, Thomas J. Kuehl, Tristi W. Muir

    Research output: Contribution to journalArticle

    48 Scopus citations


    Objective: We sought to evaluate the effects of graft type, site of implantation, and ovariectomy on the long-term histologic response to graft materials used in pelvic reconstructive surgery. Study Design: In all, 45 rabbits underwent ovariectomy or sham laparotomy and were implanted with polypropylene (PP) mesh (n = 23) or cross-linked porcine dermis (PS) (n = 22) in the vagina and abdomen. Grafts were harvested 9 months later and were processed for histology to evaluate the host inflammatory response and degree of tissue incorporation within the grafts. Results: Polypropylene induced a milder (P < .007), more uniform response than PS, whereas PS elicited a more variable response and degraded by 9 months. Vaginal grafts had higher scores for inflammation (P = .005) and neovascularization (P < .001), and had lower scores for fibroblastic proliferation (P < .001) than abdominal grafts. Ovariectomy had no effect (P > .05). Conclusion: Synthetic and biologic grafts evoke different foreign body responses, which may have implications for surgical outcomes in women.

    Original languageEnglish (US)
    JournalAmerican Journal of Obstetrics and Gynecology
    Issue number5
    StatePublished - May 2009



    • biologic graft
    • pelvic organ prolapse
    • polypropylene mesh
    • porcine dermis
    • rabbit model
    • synthetic graft

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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