Long-term histologic response to synthetic and biologic graft materials implanted in the vagina and abdomen of a rabbit model

Lisa M. Pierce, Arundhati Rao, Shannon S. Baumann, Jocylen E. Glassberg, Thomas J. Kuehl, Tristi W. Muir

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    48 Scopus citations

    Abstract

    Objective: We sought to evaluate the effects of graft type, site of implantation, and ovariectomy on the long-term histologic response to graft materials used in pelvic reconstructive surgery. Study Design: In all, 45 rabbits underwent ovariectomy or sham laparotomy and were implanted with polypropylene (PP) mesh (n = 23) or cross-linked porcine dermis (PS) (n = 22) in the vagina and abdomen. Grafts were harvested 9 months later and were processed for histology to evaluate the host inflammatory response and degree of tissue incorporation within the grafts. Results: Polypropylene induced a milder (P < .007), more uniform response than PS, whereas PS elicited a more variable response and degraded by 9 months. Vaginal grafts had higher scores for inflammation (P = .005) and neovascularization (P < .001), and had lower scores for fibroblastic proliferation (P < .001) than abdominal grafts. Ovariectomy had no effect (P > .05). Conclusion: Synthetic and biologic grafts evoke different foreign body responses, which may have implications for surgical outcomes in women.

    Original languageEnglish (US)
    JournalAmerican Journal of Obstetrics and Gynecology
    Volume200
    Issue number5
    DOIs
    StatePublished - May 2009

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    Keywords

    • biologic graft
    • pelvic organ prolapse
    • polypropylene mesh
    • porcine dermis
    • rabbit model
    • synthetic graft

    ASJC Scopus subject areas

    • Obstetrics and Gynecology

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