Long-term hydrogen peroxide exposure potentiates anoikis resistance and anchorage-independent growth in lung carcinoma cells

Hasseri Halim, Pithi Chanvorachote

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Hydrogen peroxide (H2O2) is upregulated in tumour microenvironments and may contribute to effects on metastatic cancer cells. This study demonstrates that treatment of lung carcinoma and melanoma cells with H2O2 for 14 days results in an induction of anoikis resistance and growth in an anchorage-independent condition. H2O2 exposure increased the Cav-1 (caveolin-1) level through an increase of Cav-1 mRNA with minimal effect on protein degradation. Upregulation of Cav-1 induced anoikis resistance and facilitated growth in a detached manner. The findings show a novel role of hydrogen peroxide in the regulation of metastatic potential of cancer cells.

Original languageEnglish (US)
Pages (from-to)1055-1066
Number of pages12
JournalCell Biology International
Volume36
Issue number11
DOIs
StatePublished - Nov 1 2012

Keywords

  • Anoikis
  • Caveolin-1
  • Hydrogen peroxide
  • Long-term
  • Lung cancer

ASJC Scopus subject areas

  • Cell Biology

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