Long-term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis

Anum Ali, Dennis Mishler, Tim Taber, David Agarwal, Muhammad Yaqub, Muhammad Mujtaba, William Goggins, Asif Sharfuddin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Our aim was to study the long-term outcomes of all transplant recipients who underwent angiography for suspected TRAS at our institution. The patients were divided into TRAS+ve and TRAS-ve groups based upon angiographically confirmed results. TRAS was confirmed in 58.1% of 74 patients with median time of 8.9 months. Primary angioplasty alone was performed in 56% of patients with TRAS, while the remaining had PTA with stent (PTAS). There was reduction in systolic and diastolic BP (165 ± 19-136 ± 15 mmHg and 82 ± 14 mmHg to 68 ± 12 mmHg; p < 0.05) and number of antihypertensive drugs (3.5 ± 0.9-2.7 ± 1.0; p < 0.05). Overall, graft survival and patient survival from time of transplant were similar in both groups. Graft function was similar for the patients with treated TRAS+ve as compared to TRAS-ve over time. Graft survival and patient survival when compared to an age- and year of transplant-matched cohort control group were also similar. In conclusion, angiography for suspected TRAS is more likely to yield a confirmatory result early in the transplant course as compared to late. Treatment of TRAS in these patients had sustained long-term graft function. Alternative etiologies of HTN and graft dysfunction should be sought for recipients further out from transplant.

Original languageEnglish (US)
Pages (from-to)747-755
Number of pages9
JournalClinical Transplantation
Volume29
Issue number9
DOIs
StatePublished - Sep 1 2015
Externally publishedYes

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Renal Artery Obstruction
Angiography
Transplants
Graft Survival
Survival
Transplant Recipients
Angioplasty
Antihypertensive Agents
Stents
Control Groups

Keywords

  • Graft function
  • Graft survival
  • Hypertension
  • Kidney transplant
  • Transplant renal artery stenosis

ASJC Scopus subject areas

  • Transplantation

Cite this

Long-term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis. / Ali, Anum; Mishler, Dennis; Taber, Tim; Agarwal, David; Yaqub, Muhammad; Mujtaba, Muhammad; Goggins, William; Sharfuddin, Asif.

In: Clinical Transplantation, Vol. 29, No. 9, 01.09.2015, p. 747-755.

Research output: Contribution to journalArticle

Ali, Anum ; Mishler, Dennis ; Taber, Tim ; Agarwal, David ; Yaqub, Muhammad ; Mujtaba, Muhammad ; Goggins, William ; Sharfuddin, Asif. / Long-term outcomes of transplant recipients referred for angiography for suspected transplant renal artery stenosis. In: Clinical Transplantation. 2015 ; Vol. 29, No. 9. pp. 747-755.
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AB - Our aim was to study the long-term outcomes of all transplant recipients who underwent angiography for suspected TRAS at our institution. The patients were divided into TRAS+ve and TRAS-ve groups based upon angiographically confirmed results. TRAS was confirmed in 58.1% of 74 patients with median time of 8.9 months. Primary angioplasty alone was performed in 56% of patients with TRAS, while the remaining had PTA with stent (PTAS). There was reduction in systolic and diastolic BP (165 ± 19-136 ± 15 mmHg and 82 ± 14 mmHg to 68 ± 12 mmHg; p < 0.05) and number of antihypertensive drugs (3.5 ± 0.9-2.7 ± 1.0; p < 0.05). Overall, graft survival and patient survival from time of transplant were similar in both groups. Graft function was similar for the patients with treated TRAS+ve as compared to TRAS-ve over time. Graft survival and patient survival when compared to an age- and year of transplant-matched cohort control group were also similar. In conclusion, angiography for suspected TRAS is more likely to yield a confirmatory result early in the transplant course as compared to late. Treatment of TRAS in these patients had sustained long-term graft function. Alternative etiologies of HTN and graft dysfunction should be sought for recipients further out from transplant.

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