Long-term persistance of the pathophysiologic response to severe burn injury

Marc G. Jeschke, Gerd G. Gauglitz, Gabriela A. Kulp, Celeste Finnerty, Felicia N. Williams, Robert Kraft, Oscar Suman, Ronald P. Mlcak, David Herndon

Research output: Contribution to journalArticle

223 Citations (Scopus)

Abstract

Background: Main contributors to adverse outcomes in severely burned pediatric patients are profound and complex metabolic changes in response to the initial injury. It is currently unknown how long these conditions persist beyond the acute phase post-injury. The aim of the present study was to examine the persistence of abnormalities of various clinical parameters commonly utilized to assess the degree hypermetabolic and inflammatory alterations in severely burned children for up to three years post-burn to identify patient specific therapeutic needs and interventions. Methodology/Principal Findings: Patients: Nine-hundred seventy-seven severely burned pediatric patients with burns over 30% of the total body surface admitted to our institution between 1998 and 2008 were enrolled in this study and compared to a cohort non-burned, non-injured children. Demographics and clinical outcomes, hypermetabolism, body composition, organ function, inflammatory and acute phase responses were determined at admission and subsequent regular intervals for up to 36 months post-burn. Statistical analysis was performed using One-way ANOVA, Student's t-test with Bonferroni correction where appropriate with significance accepted at p<0.05. Resting energy expenditure, body composition, metabolic markers, cardiac and organ function clearly demonstrated that burn caused profound alterations for up to three years post-burn demonstrating marked and prolonged hypermetabolism, p<0.05. Along with increased hypermetabolism, significant elevation of cortisol, catecholamines, cytokines, and acute phase proteins indicate that burn patients are in a hyperinflammatory state for up to three years post-burn p<0.05. Conclusions: Severe burn injury leads to a much more profound and prolonged hypermetabolic and hyperinflammatory response than previously shown. Given the tremendous adverse events associated with the hypermetabolic and hyperinflamamtory responses, we now identified treatment needs for severely burned patients for a much more prolonged time.

Original languageEnglish (US)
Article numbere21245
JournalPLoS One
Volume6
Issue number7
DOIs
StatePublished - 2011

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burns (injuries)
Pediatrics
Burns
Acute-Phase Proteins
Wounds and Injuries
Analysis of variance (ANOVA)
Chemical analysis
Catecholamines
Hydrocortisone
Statistical methods
Students
Cytokines
Body Composition
body composition
resting energy expenditure
Acute-Phase Reaction
acute phase proteins
catecholamines
Energy Metabolism
cortisol

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Jeschke, M. G., Gauglitz, G. G., Kulp, G. A., Finnerty, C., Williams, F. N., Kraft, R., ... Herndon, D. (2011). Long-term persistance of the pathophysiologic response to severe burn injury. PLoS One, 6(7), [e21245]. https://doi.org/10.1371/journal.pone.0021245

Long-term persistance of the pathophysiologic response to severe burn injury. / Jeschke, Marc G.; Gauglitz, Gerd G.; Kulp, Gabriela A.; Finnerty, Celeste; Williams, Felicia N.; Kraft, Robert; Suman, Oscar; Mlcak, Ronald P.; Herndon, David.

In: PLoS One, Vol. 6, No. 7, e21245, 2011.

Research output: Contribution to journalArticle

Jeschke, MG, Gauglitz, GG, Kulp, GA, Finnerty, C, Williams, FN, Kraft, R, Suman, O, Mlcak, RP & Herndon, D 2011, 'Long-term persistance of the pathophysiologic response to severe burn injury', PLoS One, vol. 6, no. 7, e21245. https://doi.org/10.1371/journal.pone.0021245
Jeschke, Marc G. ; Gauglitz, Gerd G. ; Kulp, Gabriela A. ; Finnerty, Celeste ; Williams, Felicia N. ; Kraft, Robert ; Suman, Oscar ; Mlcak, Ronald P. ; Herndon, David. / Long-term persistance of the pathophysiologic response to severe burn injury. In: PLoS One. 2011 ; Vol. 6, No. 7.
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