Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2

Gregg N. Milligan, Michael G. Meador, Chin Fun Chu, Christal G. Young, Talitha L. Martin, Nigel Bourne

Research output: Contribution to journalArticle

13 Scopus citations


The tissue sites of long-term herpes simplex virus type 2 (HSV-2)-specific antibody production in mice and guinea pigs were identified. In addition to secondary lymphoid tissue and bone marrow, HSV-specific plasma cells were detected in spinal cords of mice up to 10 months after intravaginal inoculation with a thymidine kinase-deficient HSV-2 strain and in lumbosacral ganglia and spinal cords of guinea pigs inoculated with HSV-2 strain MS. The long-term retention of virus-specific plasma cells in the peripheral and central nervous systems following HSV infection may be important for resistance to reinfection of neuronal tissues or may play a role in modulation of reactivation from latency.

Original languageEnglish (US)
Pages (from-to)11537-11540
Number of pages4
JournalJournal of virology
Issue number17
StatePublished - Sep 1 2005


ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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