Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2

Gregg Milligan, Michael G. Meador, Chin Fun Chu, Christal G. Young, Talitha L. Martin, Nigel Bourne

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The tissue sites of long-term herpes simplex virus type 2 (HSV-2)-specific antibody production in mice and guinea pigs were identified. In addition to secondary lymphoid tissue and bone marrow, HSV-specific plasma cells were detected in spinal cords of mice up to 10 months after intravaginal inoculation with a thymidine kinase-deficient HSV-2 strain and in lumbosacral ganglia and spinal cords of guinea pigs inoculated with HSV-2 strain MS. The long-term retention of virus-specific plasma cells in the peripheral and central nervous systems following HSV infection may be important for resistance to reinfection of neuronal tissues or may play a role in modulation of reactivation from latency.

Original languageEnglish (US)
Pages (from-to)11537-11540
Number of pages4
JournalJournal of Virology
Volume79
Issue number17
DOIs
StatePublished - Sep 2005

Fingerprint

Human herpesvirus 2
Sensory Ganglia
Human Herpesvirus 2
plasma cells
Plasma Cells
spinal cord
Spinal Cord
Viruses
guinea pigs
viruses
Guinea Pigs
thymidine kinase
peripheral nervous system
Thymidine Kinase
mice
Peripheral Nervous System
Lymphoid Tissue
antibody formation
Ganglia
bone marrow

ASJC Scopus subject areas

  • Immunology

Cite this

Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2. / Milligan, Gregg; Meador, Michael G.; Chu, Chin Fun; Young, Christal G.; Martin, Talitha L.; Bourne, Nigel.

In: Journal of Virology, Vol. 79, No. 17, 09.2005, p. 11537-11540.

Research output: Contribution to journalArticle

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