Long-term results of excision followed by radiofrequency ablation as the sole means of local therapy for breast cancer

Misti Wilson, Soheila Korourian, Cristiano Boneti, Laura Adkins, Brian Badgwell, Jeannette Lee, Vicki Klimberg

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Introduction. Clinical trials have yet to find a size or grade of invasive cancer which can be treated with lumpectomy alone due to the higher local recurrence (LR) rate without radiation (XRT). Excision followed by radiofrequency ablation (eRFA) is an intraoperative method which utilizes heat to create an additional tumor-free zone around the lumpectomy cavity. We hypothesized that eRFA after lumpectomy for invasive breast cancer could reduce the need for re-excision in close margins and potentially maintain local control without the need for XRT. Methods. This institutional review board-A pproved study from July 2002 to December 2010 involved patients undergoing eRFA. A standard lumpectomy was performed and then the RFA probe was deployed 1 cm circumferentially into the walls of the lumpectomy cavity and maintained at 100 °C for 15 min. Validated doppler sonography was used to determine final ablation size. Results. Seventy-three patients (mean age of 68.8 ± 10.9 years) with invasive cancer who had an average tumor size of 1.0 ± 0.54 cm (range of 0.2-2.6 cm) underwent eRFA. Margins were negative in 54, close in 10, focally positive in 6, and grossly positive in 3 patients. Sixteen out of 19 (84 %) of patients with close or positive margins were spared of re-excision. Median follow-up was 55 ± 21 months. Only one patient (1.3 %) developed an in site recurrence. There were three recurrences, elsewhere. Conclusions. Long-term follow-up suggests that eRFA may reduce the need for re- excision as well as reduce LR for invasive breast cancer treated without XRT.

Original languageEnglish (US)
Pages (from-to)3192-3198
Number of pages7
JournalAnnals of Surgical Oncology
Volume19
Issue number10
DOIs
StatePublished - Oct 2012
Externally publishedYes

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Segmental Mastectomy
Breast Neoplasms
Recurrence
Neoplasms
Therapeutics
Doppler Ultrasonography
Research Ethics Committees
Hot Temperature
Clinical Trials
Radiation

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Long-term results of excision followed by radiofrequency ablation as the sole means of local therapy for breast cancer. / Wilson, Misti; Korourian, Soheila; Boneti, Cristiano; Adkins, Laura; Badgwell, Brian; Lee, Jeannette; Klimberg, Vicki.

In: Annals of Surgical Oncology, Vol. 19, No. 10, 10.2012, p. 3192-3198.

Research output: Contribution to journalArticle

Wilson, Misti ; Korourian, Soheila ; Boneti, Cristiano ; Adkins, Laura ; Badgwell, Brian ; Lee, Jeannette ; Klimberg, Vicki. / Long-term results of excision followed by radiofrequency ablation as the sole means of local therapy for breast cancer. In: Annals of Surgical Oncology. 2012 ; Vol. 19, No. 10. pp. 3192-3198.
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abstract = "Introduction. Clinical trials have yet to find a size or grade of invasive cancer which can be treated with lumpectomy alone due to the higher local recurrence (LR) rate without radiation (XRT). Excision followed by radiofrequency ablation (eRFA) is an intraoperative method which utilizes heat to create an additional tumor-free zone around the lumpectomy cavity. We hypothesized that eRFA after lumpectomy for invasive breast cancer could reduce the need for re-excision in close margins and potentially maintain local control without the need for XRT. Methods. This institutional review board-A pproved study from July 2002 to December 2010 involved patients undergoing eRFA. A standard lumpectomy was performed and then the RFA probe was deployed 1 cm circumferentially into the walls of the lumpectomy cavity and maintained at 100 °C for 15 min. Validated doppler sonography was used to determine final ablation size. Results. Seventy-three patients (mean age of 68.8 ± 10.9 years) with invasive cancer who had an average tumor size of 1.0 ± 0.54 cm (range of 0.2-2.6 cm) underwent eRFA. Margins were negative in 54, close in 10, focally positive in 6, and grossly positive in 3 patients. Sixteen out of 19 (84 {\%}) of patients with close or positive margins were spared of re-excision. Median follow-up was 55 ± 21 months. Only one patient (1.3 {\%}) developed an in site recurrence. There were three recurrences, elsewhere. Conclusions. Long-term follow-up suggests that eRFA may reduce the need for re- excision as well as reduce LR for invasive breast cancer treated without XRT.",
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AU - Lee, Jeannette

AU - Klimberg, Vicki

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