Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patients

Philipp Hendrix, Paul M. Foreman, Sebastian Senger, Benedikt W. Burkhardt, Mark R. Harrigan, Winfield S. Fisher, Nilesh A. Vyas, Robert H. Lipsky, Beverly C. Walters, R. Shane Tubbs, Mohammadali Mohajel Shoja, Christoph J. Griessenauer

Research output: Contribution to journalArticle

Abstract

Loss of consciousness (LOC) at presentation with aneurysmal subarachnoid hemorrhage (aSAH) has been associated with early brain injury and poor functional outcome. The impact of LOC on the clinical course after aSAH deserves further exploration. A retrospective analysis of 149 aSAH patients who were prospectively enrolled in the Cerebral Aneurysm Renin Angiotensin Study (CARAS) between 2012 and 2015 was performed. The impact of LOC was analyzed with emphasis on patients presenting in excellent or good neurological condition (Hunt and Hess 1 and 2). A total of 50/149 aSAH patients (33.6%) experienced LOC at presentation. Loss of consciousness was associated with severity of neurological condition upon admission (Hunt and Hess, World Federation of Neurosurgical Societies (WFNS), Glasgow Coma Scale (GCS) grade), hemorrhage burden on initial head CT (Fisher CT grade), acute hydrocephalus, cardiac instability, and nosocomial infection. Of Hunt and Hess grade 1 and 2 patients, 21/84 (25.0%) suffered LOC at presentation. Cardiac instability and nosocomial infection were significantly more frequent in these patients. In multivariable analysis, LOC was the predominant predictor of cardiac instability and nosocomial infection. Loss of consciousness at presentation with aSAH is associated with an increased rate of complications, even in good-grade patients. The presence of LOC may identify good-grade patients at risk for complications such as cardiac instability and nosocomial infection.

Original languageEnglish (US)
JournalNeurosurgical Review
DOIs
StatePublished - Jan 1 2019

Fingerprint

Unconsciousness
Subarachnoid Hemorrhage
Cross Infection
Glasgow Coma Scale
Angiotensins
Intracranial Aneurysm
Hydrocephalus
Renin
Brain Injuries
Head
Hemorrhage

Keywords

  • Aneurysm
  • Loss of consciousness
  • Subarachnoid hemorrhage

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Hendrix, P., Foreman, P. M., Senger, S., Burkhardt, B. W., Harrigan, M. R., Fisher, W. S., ... Griessenauer, C. J. (2019). Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patients. Neurosurgical Review. https://doi.org/10.1007/s10143-019-01142-z

Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patients. / Hendrix, Philipp; Foreman, Paul M.; Senger, Sebastian; Burkhardt, Benedikt W.; Harrigan, Mark R.; Fisher, Winfield S.; Vyas, Nilesh A.; Lipsky, Robert H.; Walters, Beverly C.; Tubbs, R. Shane; Mohajel Shoja, Mohammadali; Griessenauer, Christoph J.

In: Neurosurgical Review, 01.01.2019.

Research output: Contribution to journalArticle

Hendrix, P, Foreman, PM, Senger, S, Burkhardt, BW, Harrigan, MR, Fisher, WS, Vyas, NA, Lipsky, RH, Walters, BC, Tubbs, RS, Mohajel Shoja, M & Griessenauer, CJ 2019, 'Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patients', Neurosurgical Review. https://doi.org/10.1007/s10143-019-01142-z
Hendrix, Philipp ; Foreman, Paul M. ; Senger, Sebastian ; Burkhardt, Benedikt W. ; Harrigan, Mark R. ; Fisher, Winfield S. ; Vyas, Nilesh A. ; Lipsky, Robert H. ; Walters, Beverly C. ; Tubbs, R. Shane ; Mohajel Shoja, Mohammadali ; Griessenauer, Christoph J. / Loss of consciousness at onset of aneurysmal subarachnoid hemorrhage in good-grade patients. In: Neurosurgical Review. 2019.
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