Loss of dorsal root ganglion cells concomitant with dorsal root axon sprouting following segmental nerve lesions

H. A. Lekan, K. Chung, Y. W. Yoon, Jin Chung, R. E. Coggeshall

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

Tight ligation of the fifth and sixth lumbar segmental nerves in the rat provides a model of neuropathic pain. We used this model to assess the changes in primary afferent input to the dorsal horn in neuropathic pain syndromes. Dorsal roots and ganglia were examined for up to 32 weeks following segmental nerve ligation. Stereologic and morphometric techniques revealed a notable decrease in the numbers of dorsal root ganglion cells and unmyelinated dorsal root axons by six weeks post-injury. By 32 weeks following segmental nerve ligations, the numbers of dorsal root ganglion cells have dropped to 50% of preligation levels while the numbers of dorsal root axons have increased to normal levels predominantly due to sprouting of myelinated fibres. These findings indicate that although there is a great loss of dorsal root ganglion cells, there is dramatic sprouting of myelinated fibres and possibly some sprouting of unmyelinated fibres in the dorsal roots. Additionally, a difference in the responses of unmyelinated and myelinated fibres to this peripheral nerve injury is revealed. These changes in dorsal root ganglion cells and their central axons may underlie certain aspects of abnormal pain syndromes because of changes in the types and quantity of input the dorsal horn receives.

Original languageEnglish
Pages (from-to)527-534
Number of pages8
JournalNeuroscience
Volume81
Issue number2
DOIs
StatePublished - Sep 8 1997

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Spinal Nerve Roots
Spinal Ganglia
Axons
Ligation
Neuralgia
Peripheral Nerve Injuries
Pain
Wounds and Injuries
Spinal Cord Dorsal Horn

Keywords

  • Neuropathic pain
  • Numbers
  • Peripheral nerve injury
  • Primary afferents

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Loss of dorsal root ganglion cells concomitant with dorsal root axon sprouting following segmental nerve lesions. / Lekan, H. A.; Chung, K.; Yoon, Y. W.; Chung, Jin; Coggeshall, R. E.

In: Neuroscience, Vol. 81, No. 2, 08.09.1997, p. 527-534.

Research output: Contribution to journalArticle

Lekan, H. A. ; Chung, K. ; Yoon, Y. W. ; Chung, Jin ; Coggeshall, R. E. / Loss of dorsal root ganglion cells concomitant with dorsal root axon sprouting following segmental nerve lesions. In: Neuroscience. 1997 ; Vol. 81, No. 2. pp. 527-534.
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