Abstract
We hypothesize that the accumulation of tetrodotoxin (TTX) sensitive sodium channels in injured dorsal root ganglion (DRG) neurons plays a critically important role in the generation of ectopic discharges and mechanical allodynia after peripheral nerve injury. Using the segmental spinal nerve (L5) ligation model of neuropathic pain, this hypothesis was tested by examining the effect of TTX on the mechanical sensitivity of the affected hind paw. Various concentrations of TTX were applied topically to the L5 DRG by using chronically implanted polyethylene tubing. The data showed that application of TTX at low doses (12.5-50 nM), which are far less than those needed for blocking action potential conduction, produced a significant elevation of mechanical threshold in the paw for foot withdrawals, a sign of reduced allodynic behaviors. The data suggest that TTX-sensitive subtypes of sodium channels play an important role in maintaining allodynic behaviors in an animal model of neuropathic pain. Copyright (C) 2000 Elsevier Science B.V.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 98-103 |
| Number of pages | 6 |
| Journal | Brain Research |
| Volume | 871 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 14 2000 |
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Keywords
- Allodynia
- Dorsal root ganglion
- Ectopic discharge
- Local anesthetic
- Sodium channel
- Tetrodotoxin
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model. / Lyu, Yeoung Su; Park, Soon Kwon; Chung, Kyungsoon; Chung, Jin.
In: Brain Research, Vol. 871, No. 1, 14.07.2000, p. 98-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model
AU - Lyu, Yeoung Su
AU - Park, Soon Kwon
AU - Chung, Kyungsoon
AU - Chung, Jin
PY - 2000/7/14
Y1 - 2000/7/14
N2 - We hypothesize that the accumulation of tetrodotoxin (TTX) sensitive sodium channels in injured dorsal root ganglion (DRG) neurons plays a critically important role in the generation of ectopic discharges and mechanical allodynia after peripheral nerve injury. Using the segmental spinal nerve (L5) ligation model of neuropathic pain, this hypothesis was tested by examining the effect of TTX on the mechanical sensitivity of the affected hind paw. Various concentrations of TTX were applied topically to the L5 DRG by using chronically implanted polyethylene tubing. The data showed that application of TTX at low doses (12.5-50 nM), which are far less than those needed for blocking action potential conduction, produced a significant elevation of mechanical threshold in the paw for foot withdrawals, a sign of reduced allodynic behaviors. The data suggest that TTX-sensitive subtypes of sodium channels play an important role in maintaining allodynic behaviors in an animal model of neuropathic pain. Copyright (C) 2000 Elsevier Science B.V.
AB - We hypothesize that the accumulation of tetrodotoxin (TTX) sensitive sodium channels in injured dorsal root ganglion (DRG) neurons plays a critically important role in the generation of ectopic discharges and mechanical allodynia after peripheral nerve injury. Using the segmental spinal nerve (L5) ligation model of neuropathic pain, this hypothesis was tested by examining the effect of TTX on the mechanical sensitivity of the affected hind paw. Various concentrations of TTX were applied topically to the L5 DRG by using chronically implanted polyethylene tubing. The data showed that application of TTX at low doses (12.5-50 nM), which are far less than those needed for blocking action potential conduction, produced a significant elevation of mechanical threshold in the paw for foot withdrawals, a sign of reduced allodynic behaviors. The data suggest that TTX-sensitive subtypes of sodium channels play an important role in maintaining allodynic behaviors in an animal model of neuropathic pain. Copyright (C) 2000 Elsevier Science B.V.
KW - Allodynia
KW - Dorsal root ganglion
KW - Ectopic discharge
KW - Local anesthetic
KW - Sodium channel
KW - Tetrodotoxin
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U2 - 10.1016/S0006-8993(00)02451-3
DO - 10.1016/S0006-8993(00)02451-3
M3 - Article
VL - 871
SP - 98
EP - 103
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -