Low-dose versus high-dose heparinization during arteriovenous carbon dioxide removal

J. A. Murphy, C. M. Savage, S. K. Alpard, D. J. Deyo, J. B. Jayroe, J. B. Zwischenberger

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    The purpose of this study was to compare low-dose (LD) and high-dose (HD) systemic heparinization in a prospective randomized study of arteriovenous carbon dioxide removal (AVCO2R) during acute respiratory distress syndrome, using a commercially available heparin-coated oxygenator. Adult sheep (n = 13) received an LD50 smoke inhalation and 40% TBSA third degree cutaneous flame burn injury. At 40-48 h post-injury, animals underwent cannulation of the carotid artery and jugular vein and were then randomized to HD heparin (activated clotting time, ACT > 300 s, n = 6) and LD heparin (ACT < 200 s, n = 7) and placed on AVCO2R for approximately 72 h using an oxygenator with the Trillium Bio-Passive Surface TM. Mean ACTs were significantly different, as expected (HD: 446 ± 26 s, LD: 213 ± 12 s, p < 0.05). AVCO2R shunt flow averaged approximately 13% of cardiac output with mean CO2 removal similar in HD and LD, p = NS. The hematocrit, platelet count, and fibrin degradation products for the two groups were not different. No differences in thrombosis or bleeding were noted. In conclusion, LD systemic heparin (ACT < 200 s) with a heparincoated oxygenator does not increase thrombogenicity during AVCO2R for smoke/burn-induced severe lung injury in sheep.

    Original languageEnglish (US)
    Pages (from-to)460-468
    Number of pages9
    JournalPerfusion
    Volume16
    Issue number6
    StatePublished - 2001

    Fingerprint

    Oxygenators
    Carbon Dioxide
    Heparin
    Carbon dioxide
    animal
    Smoke
    Trillium
    Sheep
    Group
    Fibrin Fibrinogen Degradation Products
    Lethal Dose 50
    Jugular Veins
    Adult Respiratory Distress Syndrome
    Wounds and Injuries
    Lung Injury
    Platelets
    Platelet Count
    Burns
    Hematocrit
    Carotid Arteries

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine

    Cite this

    Murphy, J. A., Savage, C. M., Alpard, S. K., Deyo, D. J., Jayroe, J. B., & Zwischenberger, J. B. (2001). Low-dose versus high-dose heparinization during arteriovenous carbon dioxide removal. Perfusion, 16(6), 460-468.

    Low-dose versus high-dose heparinization during arteriovenous carbon dioxide removal. / Murphy, J. A.; Savage, C. M.; Alpard, S. K.; Deyo, D. J.; Jayroe, J. B.; Zwischenberger, J. B.

    In: Perfusion, Vol. 16, No. 6, 2001, p. 460-468.

    Research output: Contribution to journalArticle

    Murphy, JA, Savage, CM, Alpard, SK, Deyo, DJ, Jayroe, JB & Zwischenberger, JB 2001, 'Low-dose versus high-dose heparinization during arteriovenous carbon dioxide removal', Perfusion, vol. 16, no. 6, pp. 460-468.
    Murphy JA, Savage CM, Alpard SK, Deyo DJ, Jayroe JB, Zwischenberger JB. Low-dose versus high-dose heparinization during arteriovenous carbon dioxide removal. Perfusion. 2001;16(6):460-468.
    Murphy, J. A. ; Savage, C. M. ; Alpard, S. K. ; Deyo, D. J. ; Jayroe, J. B. ; Zwischenberger, J. B. / Low-dose versus high-dose heparinization during arteriovenous carbon dioxide removal. In: Perfusion. 2001 ; Vol. 16, No. 6. pp. 460-468.
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