Low infectious complications in segmental living related small bowel transplatation in adults

Luca Cicalese, Pierpaolo Sileri, Massimo Asolati, Cristiana Rastellini, Herand Abcarian, Enrico Benedetti

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Clinical small bowel transplantation (SBTx) has been associated with a high rate of infectious complications. Laparotomy, preservation injury, abnormal motility, lymphatic disruption, aberrant systemic venous drainage, rejection and antibiotic therapy could all be implicated in the etiology of these complications. In addition to the underlying disease, total parental nutrition could determine infections and liver impairment. Recently, standardized techniques for segmental living related SBTx (LR-SBTx) have been developed. This technique allows reduction of some of these factors, thus resulting in a reduced incidence of infections. We report the infectious complications observed in 3 patients with short bowel syndrome treated with LR-SBTx at our institution. A segment of 180-200 cm of ileum was transplanted with a neglectably short cold ischemia time (CIT). The donor bowel was decontaminated. Oral tacrolimus, prednisone and IV induction with ATG were used for immunosuppression. Blood, stool, urine, sputum and peritoneal fluids were collected and cultured as a routine surveillance. All recipients are alive with a current follow-up time up to 21 months. No bacterial infections were observed during the post-transplant period. One patient developed cytomegalovirus (CMV) enteritis 4 months after LR-SBTx and was treated successfully with IV ganciclovir. In our limited experience, LR-SBTx is associated with a low infection rate. This could be due to optimal graft decontamination, short CIT and to the reduced incidence of rejection and lower immunosuppression used in this immunologically well-matched combination.

Original languageEnglish (US)
Pages (from-to)567-571
Number of pages5
JournalClinical Transplantation
Volume14
Issue number6
DOIs
StatePublished - 2000
Externally publishedYes

Fingerprint

Cold Ischemia
Immunosuppression
Infection
Short Bowel Syndrome
Transplants
Ganciclovir
Decontamination
Enteritis
Ascitic Fluid
Incidence
Tacrolimus
Prednisone
Sputum
Cytomegalovirus
Ileum
Bacterial Infections
Laparotomy
Drainage
Transplantation
Tissue Donors

Keywords

  • Bacterial translocation
  • Infection
  • Living related
  • Small bowel transplant

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Low infectious complications in segmental living related small bowel transplatation in adults. / Cicalese, Luca; Sileri, Pierpaolo; Asolati, Massimo; Rastellini, Cristiana; Abcarian, Herand; Benedetti, Enrico.

In: Clinical Transplantation, Vol. 14, No. 6, 2000, p. 567-571.

Research output: Contribution to journalArticle

Cicalese, Luca ; Sileri, Pierpaolo ; Asolati, Massimo ; Rastellini, Cristiana ; Abcarian, Herand ; Benedetti, Enrico. / Low infectious complications in segmental living related small bowel transplatation in adults. In: Clinical Transplantation. 2000 ; Vol. 14, No. 6. pp. 567-571.
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