Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia

CNS HIV Antiretroviral Therapy Effects Research CHARTER Group

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients. Objective: To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND). Methods: One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used. Results: FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15). Conclusion: FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.

Original languageEnglish (US)
Pages (from-to)324-330
Number of pages7
JournalCurrent HIV Research
Volume14
Issue number4
StatePublished - Jul 1 2016

Fingerprint

Cerebrospinal Fluid
Dementia
HIV
Neurocognitive Disorders
AIDS Dementia Complex
Biomarkers
Logistic Models

Keywords

  • Biomarkers
  • Cerebrospinal fluid
  • Dementia
  • Family history
  • HIV
  • Neurocognitive impairment

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

CNS HIV Antiretroviral Therapy Effects Research CHARTER Group (2016). Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia. Current HIV Research, 14(4), 324-330.

Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia. / CNS HIV Antiretroviral Therapy Effects Research CHARTER Group.

In: Current HIV Research, Vol. 14, No. 4, 01.07.2016, p. 324-330.

Research output: Contribution to journalArticle

CNS HIV Antiretroviral Therapy Effects Research CHARTER Group 2016, 'Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia', Current HIV Research, vol. 14, no. 4, pp. 324-330.
CNS HIV Antiretroviral Therapy Effects Research CHARTER Group. Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia. Current HIV Research. 2016 Jul 1;14(4):324-330.
CNS HIV Antiretroviral Therapy Effects Research CHARTER Group. / Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia. In: Current HIV Research. 2016 ; Vol. 14, No. 4. pp. 324-330.
@article{e226d49ea3e446939c59944d7c2275a6,
title = "Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia",
abstract = "Background: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients. Objective: To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND). Methods: One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used. Results: FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15). Conclusion: FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.",
keywords = "Biomarkers, Cerebrospinal fluid, Dementia, Family history, HIV, Neurocognitive impairment",
author = "{CNS HIV Antiretroviral Therapy Effects Research CHARTER Group} and Fazeli, {Pariya L.} and Moore, {David J.} and Franklin, {Donald R.} and Anya Umlauf and Heaton, {Robert K.} and Collier, {Ann C.} and Marra, {Christina M.} and Clifford, {David B.} and Benjamin Gelman and Sacktor, {Ned C.} and Susan Morgello and Simpson, {David M.} and McCutchan, {John A.} and Igor Grant and Letendre, {Scott L.} and Igor Grant and Letendre, {Scott L.} and Ellis, {Ronald J.} and Marcotte, {Thomas D.} and Donald Franklin and Ellis, {Ronald J.} and McCutchan, {J. Allen} and Scott Letendre and Smith, {Davey M.} and Heaton, {Robert K.} and {Hampton Atkinson}, J. and Christine Fennema-Notestine and Taylor, {Michael J.} and Rebecca Theilmann and Gamst, {Anthony C.} and Clint Cushman and Ian Abramson and Florin Vaida and Reena Deutsch and Justin McArthur and Vincent Rogalski and Susan Morgello and David Simpson and Letty Mintz and {Allen McCutchan}, J. and Kaori Phillips and Ann Collier and Christina Marra and Trudy Jones and Benjamin Gelman and Eleanor Head and David Clifford and Muhammad Al-Lozi and Mengesha Teshome",
year = "2016",
month = "7",
day = "1",
language = "English (US)",
volume = "14",
pages = "324--330",
journal = "Current HIV Research",
issn = "1570-162X",
publisher = "Bentham Science Publishers B.V.",
number = "4",

}

TY - JOUR

T1 - Lower CSF Aβ is associated with HAND in HIV-infected adults with a family History of Dementia

AU - CNS HIV Antiretroviral Therapy Effects Research CHARTER Group

AU - Fazeli, Pariya L.

AU - Moore, David J.

AU - Franklin, Donald R.

AU - Umlauf, Anya

AU - Heaton, Robert K.

AU - Collier, Ann C.

AU - Marra, Christina M.

AU - Clifford, David B.

AU - Gelman, Benjamin

AU - Sacktor, Ned C.

AU - Morgello, Susan

AU - Simpson, David M.

AU - McCutchan, John A.

AU - Grant, Igor

AU - Letendre, Scott L.

AU - Grant, Igor

AU - Letendre, Scott L.

AU - Ellis, Ronald J.

AU - Marcotte, Thomas D.

AU - Franklin, Donald

AU - Ellis, Ronald J.

AU - McCutchan, J. Allen

AU - Letendre, Scott

AU - Smith, Davey M.

AU - Heaton, Robert K.

AU - Hampton Atkinson, J.

AU - Fennema-Notestine, Christine

AU - Taylor, Michael J.

AU - Theilmann, Rebecca

AU - Gamst, Anthony C.

AU - Cushman, Clint

AU - Abramson, Ian

AU - Vaida, Florin

AU - Deutsch, Reena

AU - McArthur, Justin

AU - Rogalski, Vincent

AU - Morgello, Susan

AU - Simpson, David

AU - Mintz, Letty

AU - Allen McCutchan, J.

AU - Phillips, Kaori

AU - Collier, Ann

AU - Marra, Christina

AU - Jones, Trudy

AU - Gelman, Benjamin

AU - Head, Eleanor

AU - Clifford, David

AU - Al-Lozi, Muhammad

AU - Teshome, Mengesha

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Background: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients. Objective: To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND). Methods: One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used. Results: FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15). Conclusion: FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.

AB - Background: Both family history of dementia (FHD) and lower levels of Aβ-42 are indepentently associated with worse neurocognitive functioning in HIVinfected patients. Objective: To examine the relationships between cerebrospinal fluid (CSF) Aβ-42 and FHD with HIV-associated neurocognitive disorders (HAND). Methods: One hundred eighty-three HIV+ adults underwent neuropsychological and neuromedical assessments, and determination of CSF Aβ-42 concentration and FHD (defined as a self-reported first or second-degree relative with a dementia diagnosis). Univariate analyses and multivariable logistic regressions were used. Results: FHD was not associated with HAND (p = 0.24); however, CSF Aβ-42 levels were lower (p = 0.03) in the HAND group, but were not associated with FHD (p = 0.89). Multivariable models showed a main effect of CSF Aβ-42 (p = 0.03) and a trend-level (p = 0.06) interaction between FHD and CSF Aβ-42, such that lower CSF Aβ-42 was associated with HAND in those with FHD (p < 0.01) compared to those without FHD (p = 0.83). An analysis in those with follow-up data showed that higher baseline CSF Aβ-42 was associated with lower risk of neurocognitive decline (p = 0.02). While we did not find an FHD X CSF Aβ-42 interaction (p = 0.83), when analyses were stratified by FHD, lower CSF Aβ-42 was associated at the trend-level with neurocognitive decline in the FHD group (p = 0.08) compared to the no FHD group (p = 0.15). Conclusion: FHD moderates the relationship between of CSF Aβ-42 and HAND. The findings highlight the complexities in interpreting the relationships between biomarkers of age-related neurodegeneration and HAND.

KW - Biomarkers

KW - Cerebrospinal fluid

KW - Dementia

KW - Family history

KW - HIV

KW - Neurocognitive impairment

UR - http://www.scopus.com/inward/record.url?scp=84975847294&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84975847294&partnerID=8YFLogxK

M3 - Article

VL - 14

SP - 324

EP - 330

JO - Current HIV Research

JF - Current HIV Research

SN - 1570-162X

IS - 4

ER -