Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice

Kashyap B. Choksi, L. Jackson Roberts, James H. DeFord, Jeffrey P. Rabek, John Papaconstantinou

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

F2-isoprostanes (IsoPs), lipid peroxidation products, are markers that quantitatively measure levels of oxidative stress. IsoP levels increase in tissues and serum of aging animals suggesting an increase in oxidative stress. This supports the Free Radical Theory of Aging, which proposes that elevated levels of reactive oxygen species (ROS) cause macromolecular damage, and is a factor in the age-associated decline in tissue function. Numerous studies have shown that the longevity of long-lived mutant mice correlates with their resistance to oxidative stress. However, although the Ames dwarf (DW) mice show resistance to oxidative stress, it has not been shown that these mice have inherently lower levels of ROS. Our results show that the serum and liver IsoP levels in DW mice are lower at all ages suggesting that the lower levels of endogenous ROS production in DW mice may be a factor in their resistance to oxidative stress and longevity.

Original languageEnglish (US)
Pages (from-to)761-764
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume364
Issue number4
DOIs
StatePublished - Dec 28 2007

Keywords

  • Aging
  • Ames dwarf mice
  • F-isoprostanes
  • Longevity
  • Oxidative stress

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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