Abstract
F2-isoprostanes (IsoPs), lipid peroxidation products, are markers that quantitatively measure levels of oxidative stress. IsoP levels increase in tissues and serum of aging animals suggesting an increase in oxidative stress. This supports the Free Radical Theory of Aging, which proposes that elevated levels of reactive oxygen species (ROS) cause macromolecular damage, and is a factor in the age-associated decline in tissue function. Numerous studies have shown that the longevity of long-lived mutant mice correlates with their resistance to oxidative stress. However, although the Ames dwarf (DW) mice show resistance to oxidative stress, it has not been shown that these mice have inherently lower levels of ROS. Our results show that the serum and liver IsoP levels in DW mice are lower at all ages suggesting that the lower levels of endogenous ROS production in DW mice may be a factor in their resistance to oxidative stress and longevity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 761-764 |
| Number of pages | 4 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 364 |
| Issue number | 4 |
| DOIs | |
| State | Published - Dec 28 2007 |
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Keywords
- Aging
- Ames dwarf mice
- F-isoprostanes
- Longevity
- Oxidative stress
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice. / Choksi, Kashyap B.; Roberts, L. Jackson; DeFord, James H.; Rabek, Jeffrey P.; Papaconstantinou, John.
In: Biochemical and Biophysical Research Communications, Vol. 364, No. 4, 28.12.2007, p. 761-764.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lower levels of F2-isoprostanes in serum and livers of long-lived Ames dwarf mice
AU - Choksi, Kashyap B.
AU - Roberts, L. Jackson
AU - DeFord, James H.
AU - Rabek, Jeffrey P.
AU - Papaconstantinou, John
PY - 2007/12/28
Y1 - 2007/12/28
N2 - F2-isoprostanes (IsoPs), lipid peroxidation products, are markers that quantitatively measure levels of oxidative stress. IsoP levels increase in tissues and serum of aging animals suggesting an increase in oxidative stress. This supports the Free Radical Theory of Aging, which proposes that elevated levels of reactive oxygen species (ROS) cause macromolecular damage, and is a factor in the age-associated decline in tissue function. Numerous studies have shown that the longevity of long-lived mutant mice correlates with their resistance to oxidative stress. However, although the Ames dwarf (DW) mice show resistance to oxidative stress, it has not been shown that these mice have inherently lower levels of ROS. Our results show that the serum and liver IsoP levels in DW mice are lower at all ages suggesting that the lower levels of endogenous ROS production in DW mice may be a factor in their resistance to oxidative stress and longevity.
AB - F2-isoprostanes (IsoPs), lipid peroxidation products, are markers that quantitatively measure levels of oxidative stress. IsoP levels increase in tissues and serum of aging animals suggesting an increase in oxidative stress. This supports the Free Radical Theory of Aging, which proposes that elevated levels of reactive oxygen species (ROS) cause macromolecular damage, and is a factor in the age-associated decline in tissue function. Numerous studies have shown that the longevity of long-lived mutant mice correlates with their resistance to oxidative stress. However, although the Ames dwarf (DW) mice show resistance to oxidative stress, it has not been shown that these mice have inherently lower levels of ROS. Our results show that the serum and liver IsoP levels in DW mice are lower at all ages suggesting that the lower levels of endogenous ROS production in DW mice may be a factor in their resistance to oxidative stress and longevity.
KW - Aging
KW - Ames dwarf mice
KW - F-isoprostanes
KW - Longevity
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=36048933773&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=36048933773&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2007.10.100
DO - 10.1016/j.bbrc.2007.10.100
M3 - Article
VL - 364
SP - 761
EP - 764
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -