Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration

David Croteau, Brookie M. Best, Scott Letendre, Steven S. Rossi, Ronald J. Ellis, David B. Clifford, Ann C. Collier, Benjamin Gelman, Justin C. McArthur, John Allen McCutchan, Susan Morgello, Igor Grant

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To measure maraviroc total cerebrospinal fluid (CSF) concentrations and compare them with total and unbound plasma concentrations. Total maraviroc was measured by reverse-phase high-performance liquid chromatography with tandem mass spectrometry, whereas ultrafiltration was used for unbound maraviroc. Maraviroc was detected in all nine CSF/plasma pairs with a median CSF total concentration of 2.4ng/ml. CSF concentrations exceeded the 50% inhibitory concentration of wild-type CC chemokine receptor 5-tropic HIV-1 in all specimens. CSF concentrations are lower than expected based on plasma concentrations and physicochemical characteristics. Unbound maraviroc plasma concentrations may be informative in estimating concentrations in CSF.

Original languageEnglish (US)
Pages (from-to)890-893
Number of pages4
JournalAIDS
Volume26
Issue number7
DOIs
StatePublished - Apr 24 2012

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CCR5 Receptors
Inhibitory Concentration 50
Cerebrospinal Fluid
HIV-1
Ultrafiltration
Reverse-Phase Chromatography
Tandem Mass Spectrometry
maraviroc
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration. / Croteau, David; Best, Brookie M.; Letendre, Scott; Rossi, Steven S.; Ellis, Ronald J.; Clifford, David B.; Collier, Ann C.; Gelman, Benjamin; McArthur, Justin C.; McCutchan, John Allen; Morgello, Susan; Grant, Igor.

In: AIDS, Vol. 26, No. 7, 24.04.2012, p. 890-893.

Research output: Contribution to journalArticle

Croteau, D, Best, BM, Letendre, S, Rossi, SS, Ellis, RJ, Clifford, DB, Collier, AC, Gelman, B, McArthur, JC, McCutchan, JA, Morgello, S & Grant, I 2012, 'Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration', AIDS, vol. 26, no. 7, pp. 890-893. https://doi.org/10.1097/QAD.0b013e328351f627
Croteau, David ; Best, Brookie M. ; Letendre, Scott ; Rossi, Steven S. ; Ellis, Ronald J. ; Clifford, David B. ; Collier, Ann C. ; Gelman, Benjamin ; McArthur, Justin C. ; McCutchan, John Allen ; Morgello, Susan ; Grant, Igor. / Lower than expected maraviroc concentrations in cerebrospinal fluid exceed the wild-type CC chemokine receptor 5-tropic HIV-1 50% inhibitory concentration. In: AIDS. 2012 ; Vol. 26, No. 7. pp. 890-893.
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AU - Ellis, Ronald J.

AU - Clifford, David B.

AU - Collier, Ann C.

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